Bioactive secolignans from Peperomia dindygulensis
文献类型：期刊论文
| 作者 | Wu, Jian-lin; Li, Na; Hasegawa, Toshiaki; Sakai, Jun-ichi; Mitsui, Tomokazu; Ogura, Hirotsugu; Kataoka, Takao; Oka, Seiko; Kiuchi, Miwa; Tomida, Akira |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2006-05-26 |
| 卷号 | 69期号:5页码:790-794 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0600447 |
| 文献子类 | Article |
| 英文摘要 | Thirteen secolignans, including eight new ones ( 1-8), were isolated from the EtOAc extract of Peperomia dindygulensis. The structures were mainly elucidated by 1D and 2D NMR and MS experiments, the relative configurations were determined by NOE correlations, and the absolute configurations were established by the optical rotations and CD spectra. Cytotoxicity and MDR ( multidrug resistance) reversal activity of the isolated compounds were examined. Compounds 6 and 7, peperomins B ( 10) and E ( 12), showed moderate to strong growth inhibitory activity against a malignant lung tumor cell ( VA-13) with IC50 values of 15.2, 13.5, 13.9, and 1.93 mu M, respectively, and also inhibited the growth of a normal lung fibroblast cell ( WI-38) at the same levels. Compound 7 and peperomin E ( 12) exhibited inhibitory activity against a liver tumor cell ( HepG2) with IC50 values of 22.3 and 12.1 mu M. Compounds 5 and 7 and peperomins A, B, C, and E ( 9-12) enhanced calcein accumulation in MDR 2780 cells at 25 mu g/mL. Compounds 2, 3, 7, and peperomin E ( 12) showed inhibitory activity on induction of the intercellular adhesion molecule-1 ( ICAM-1). |
| WOS关键词 | LIGNANS ; RESISTANCE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000237816700013 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273588]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Na |
| 作者单位 | 1.Japanese Fdn Canc Res, Canc Chemotherapy Ctr, Div Genome Res, Koto Ku, Tokyo 1358550, Japan 2.Niigata Univ, Grad Sch Sci & Technol, Ikarashi, Niigata 9502181, Japan 3.Niigata Univ, Dept Chem & Chem Engn, Ikarashi, Niigata 9502181, Japan 4.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 5.Tokyo Inst Technol, Ctr Biol Resources & Informat, Midori Ku, Yokohama, Kanagawa 2268501, Japan 6.Hokkaido Univ, Ctr Instrumental Anat, Kita Ku, Sapporo, Hokkaido 0600812, Japan 7.Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan |
| 推荐引用方式 GB/T 7714 | Wu, Jian-lin,Li, Na,Hasegawa, Toshiaki,et al. Bioactive secolignans from Peperomia dindygulensis[J]. JOURNAL OF NATURAL PRODUCTS,2006,69(5):790-794. |
| APA | Wu, Jian-lin.,Li, Na.,Hasegawa, Toshiaki.,Sakai, Jun-ichi.,Mitsui, Tomokazu.,...&Ando, Masayoshi.(2006).Bioactive secolignans from Peperomia dindygulensis.JOURNAL OF NATURAL PRODUCTS,69(5),790-794. |
| MLA | Wu, Jian-lin,et al."Bioactive secolignans from Peperomia dindygulensis".JOURNAL OF NATURAL PRODUCTS 69.5(2006):790-794. |
入库方式： OAI收割
来源：上海药物研究所
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