Lipase-catalyzed desymmetrization of quaternary carbon-containing 1,3-propanediols: A new entry to the asymmetric synthesis of alpha-substituted serine analogues
文献类型：期刊论文
| 作者 | Tian, Ping; Xu, Ming-Hua ; Wang, Zhi-Qian; Li, Zu-Yi; Lin, Guo-Qiang
|
| 刊名 | SYNLETT
 |
| 出版日期 | 2006-05-15 |
| 期号 | 8页码:1201-1204 |
| 关键词 | alpha-substituted serine lipase-catalyzed desymmetrization 2-nitropropane-1,3-diols |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-2006-939713 |
| 文献子类 | Article |
| 英文摘要 | A new approach to the asymmetric synthesis of alpha-substiluted serine analogues was developed. The method utilizes a lipase-catalyzed esterification desymmetrization protocol. In the presence of PPL, a series of benzyl-substituted quaternary 2-nitropropane-1,3-diols were successfully desymmetrized by selective acetylation in very good yields and enantioselectivities (up to 95% ee). |
| WOS关键词 | STEREOSELECTIVE-SYNTHESIS ; AMINO-ACIDS ; FUNGAL METABOLITES ; (+)-CONAGENIN ; DERIVATIVES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000237719500015 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273596]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lin, Guo-Qiang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Ping,Xu, Ming-Hua,Wang, Zhi-Qian,et al. Lipase-catalyzed desymmetrization of quaternary carbon-containing 1,3-propanediols: A new entry to the asymmetric synthesis of alpha-substituted serine analogues[J]. SYNLETT,2006(8):1201-1204. |
| APA | Tian, Ping,Xu, Ming-Hua,Wang, Zhi-Qian,Li, Zu-Yi,&Lin, Guo-Qiang.(2006).Lipase-catalyzed desymmetrization of quaternary carbon-containing 1,3-propanediols: A new entry to the asymmetric synthesis of alpha-substituted serine analogues.SYNLETT(8),1201-1204. |
| MLA | Tian, Ping,et al."Lipase-catalyzed desymmetrization of quaternary carbon-containing 1,3-propanediols: A new entry to the asymmetric synthesis of alpha-substituted serine analogues".SYNLETT .8(2006):1201-1204. |
入库方式： OAI收割
来源：上海药物研究所
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