Formation of glucoside conjugate of acetaminophen by fungi separated from soil
文献类型：期刊论文
| 作者 | Huang, H. H.; Lin, L. H.; Zhang, P.; Qi, X. L.; Zhong, D. F. |
| 刊名 | EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
 |
| 出版日期 | 2006-04 |
| 卷号 | 31期号:2页码:103-108 |
| 关键词 | acetaminophen drug metabolism filamentous fungi glucoside conjugation phase II reaction |
| ISSN号 | 0378-7966 |
| 文献子类 | Article |
| 英文摘要 | The phase II metabolite of acetaminophen in filamentous fungi and actinomycetes separated from soil was investigated. Fifty-four filamentous fungi and twenty-seven actinomycetes were screened to transform acetaminophen. The metabolites of acetaminophen were assayed using liquid chromatography-tandem mass spectrometry. The only metabolite was subject to enzymatic hydrolysis to confirm its structure. Acetaminophen was converted into glucoside conjugate, by filamentous fungi JX1-60, LN17-2, LN20-1 and the yield of the conjugate was 60.01%, 44.27%, 100%, respectively, and no phase I metabolites were detected. Glucoside conjugation of acetaminophen in filamentous fungi differs from the phase II metabolism of glucuronidation in humans. The fungus LN20-1 could be a suitable model to synthesize glucoside conjugate of acetaminophen. |
| WOS关键词 | PHASE-II ENZYMES ; CUNNINGHAMELLA-ELEGANS ; FILAMENTOUS FUNGI ; METABOLISM ; BIOTRANSFORMATION ; BIOACTIVATION |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000239363000008 |
| 出版者 | MEDECINE ET HYGIENE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273625]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Huang, H. H. |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Shenyang, Peoples R China 2.Shanghai Drug Metab Biotech Co Ltd, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab Res, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang, H. H.,Lin, L. H.,Zhang, P.,et al. Formation of glucoside conjugate of acetaminophen by fungi separated from soil[J]. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,2006,31(2):103-108. |
| APA | Huang, H. H.,Lin, L. H.,Zhang, P.,Qi, X. L.,&Zhong, D. F..(2006).Formation of glucoside conjugate of acetaminophen by fungi separated from soil.EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,31(2),103-108. |
| MLA | Huang, H. H.,et al."Formation of glucoside conjugate of acetaminophen by fungi separated from soil".EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 31.2(2006):103-108. |
入库方式： OAI收割
来源：上海药物研究所
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