Solubility of silybin in aqueous poly(ethylene glycol) solution.
文献类型：期刊论文
| 作者 | Bai, TC; Yan, GB; Hu, J; Zhang, HL; Huang, CG
|
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2006-02-03 |
| 卷号 | 308期号:1-2页码:100-106 |
| 关键词 | silybin poly(ethylene glycol) solubility the Universal Quasi Chemical (UNIQUAC) model |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2005.10.032 |
| 文献子类 | Article |
| 英文摘要 | Silybin is a main component in silymarin, which is an antihepatotoxic polyphenolic substance isolated from the milk thistle plant, Silybunt marianum. A major problem in the development of an oral solid dosage form of this drug is the extremely poor aqueous solubility. In present work, the solubility of silybin in aqueous poly(ethylene glycol) 6000 (PEG 6000) solution at the temperature range from 293.15 to 313.15 K was measured by a solid liquid equilibrium method. The aim of this study is to investigate the possible effect of poly(ethylene glycol) concentration and temperature on the solubility of the drug, and to reveal the solubilization capacity of the polymer for the drug. Experimental results reveal that the solubility of silybin increases with the increase both in PEG's concentration and temperature. With the increase in PEG's concentration, the transfer enthalpy and entropy for silybin from water to aqueous PEG solution increases first in a positive region, and then decreases to a negative region. The transfer enthalpy is lower than the entropy term. A modified Universal Quasi Chemical (UNIQUAC) model was used to correlate solubility data. (c) 2005 Elsevier B.V. All rights reserved. |
| WOS关键词 | SOLID DISPERSIONS ; DRUGS ; DISSOLUTION ; PREDICTION ; MIXTURES ; MODELS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000235102000013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273669]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Bai, TC |
| 作者单位 | 1.Suzhou Univ, Dept Chem & Chem Engn, Suzhou 215123, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, TC,Yan, GB,Hu, J,et al. Solubility of silybin in aqueous poly(ethylene glycol) solution.[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2006,308(1-2):100-106. |
| APA | Bai, TC,Yan, GB,Hu, J,Zhang, HL,&Huang, CG.(2006).Solubility of silybin in aqueous poly(ethylene glycol) solution..INTERNATIONAL JOURNAL OF PHARMACEUTICS,308(1-2),100-106. |
| MLA | Bai, TC,et al."Solubility of silybin in aqueous poly(ethylene glycol) solution.".INTERNATIONAL JOURNAL OF PHARMACEUTICS 308.1-2(2006):100-106. |
入库方式： OAI收割
来源：上海药物研究所
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