中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii

文献类型:期刊论文

作者Li, N; Wu, JL; Hasegawa, T; Sakai, J; Wang, LY; Kakuta, S; Furuya, Y; Tomida, A; Tsuruo, T; Ando, M
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2006-02
卷号69期号:2页码:234-239
ISSN号0163-3864
DOI10.1021/np050417o
文献子类Article
英文摘要Six new dibenzylbutyrolactone (6-11) and two new dibenzylbutanediol lignans (12, 13) were obtained from Peperomia duclouxii. The structures were elucidated mainly by the analysis of NMR and MS data. The anticancer activity against a normal (WI-38) and a simian virus 40-transformed human lung fibroblast cell (VA-13) and a hepatoma G2 cell (HepG2) and the MDR reversal activity of the isolated compounds were examined. Compound 7 showed moderate inhibitory activity against VA-13 and HepG2 with IC50 values of 23.2 and 26.4 mu M, respectively. Compound 2 inhibited the growth of HepG2 cells with an IC50 of 42.8 mu M. Compounds 2 and 13 exhibited stronger MDR reversal activity than verapamil, at 25 and 2.5 mu g/mL, respectively, and 4, 5, and 7 showed comparable activity with verapamil, at 25, 25, and 2.5 mu g/mL, respectively.
WOS关键词BUPLEURUM-SALICIFOLIUM ; RESISTANCE
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000235943400011
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/273675]  
专题中国科学院上海药物研究所
通讯作者Ando, M
作者单位1.Niigata Univ, Dept Chem & Chem Engn, Niigata 9502181, Japan
2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
3.Niigata Univ, Grad Sch Sci & Technol, Niigata, Japan
4.Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Div Genome Res, Koto Ku, Tokyo 1358550, Japan
5.Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan
推荐引用方式
GB/T 7714
Li, N,Wu, JL,Hasegawa, T,et al. Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii[J]. JOURNAL OF NATURAL PRODUCTS,2006,69(2):234-239.
APA Li, N.,Wu, JL.,Hasegawa, T.,Sakai, J.,Wang, LY.,...&Ando, M.(2006).Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.JOURNAL OF NATURAL PRODUCTS,69(2),234-239.
MLA Li, N,et al."Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii".JOURNAL OF NATURAL PRODUCTS 69.2(2006):234-239.

入库方式: OAI收割

来源:上海药物研究所

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