Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii
文献类型:期刊论文
作者 | Li, N; Wu, JL; Hasegawa, T; Sakai, J; Wang, LY; Kakuta, S; Furuya, Y; Tomida, A; Tsuruo, T; Ando, M |
刊名 | JOURNAL OF NATURAL PRODUCTS
![]() |
出版日期 | 2006-02 |
卷号 | 69期号:2页码:234-239 |
ISSN号 | 0163-3864 |
DOI | 10.1021/np050417o |
文献子类 | Article |
英文摘要 | Six new dibenzylbutyrolactone (6-11) and two new dibenzylbutanediol lignans (12, 13) were obtained from Peperomia duclouxii. The structures were elucidated mainly by the analysis of NMR and MS data. The anticancer activity against a normal (WI-38) and a simian virus 40-transformed human lung fibroblast cell (VA-13) and a hepatoma G2 cell (HepG2) and the MDR reversal activity of the isolated compounds were examined. Compound 7 showed moderate inhibitory activity against VA-13 and HepG2 with IC50 values of 23.2 and 26.4 mu M, respectively. Compound 2 inhibited the growth of HepG2 cells with an IC50 of 42.8 mu M. Compounds 2 and 13 exhibited stronger MDR reversal activity than verapamil, at 25 and 2.5 mu g/mL, respectively, and 4, 5, and 7 showed comparable activity with verapamil, at 25, 25, and 2.5 mu g/mL, respectively. |
WOS关键词 | BUPLEURUM-SALICIFOLIUM ; RESISTANCE |
WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
语种 | 英语 |
WOS记录号 | WOS:000235943400011 |
出版者 | AMER CHEMICAL SOC |
源URL | [http://119.78.100.183/handle/2S10ELR8/273675] ![]() |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Ando, M |
作者单位 | 1.Niigata Univ, Dept Chem & Chem Engn, Niigata 9502181, Japan 2.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 3.Niigata Univ, Grad Sch Sci & Technol, Niigata, Japan 4.Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Div Genome Res, Koto Ku, Tokyo 1358550, Japan 5.Univ Tokyo, Inst Mol & Cellular Biosci, Tokyo 1130032, Japan |
推荐引用方式 GB/T 7714 | Li, N,Wu, JL,Hasegawa, T,et al. Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii[J]. JOURNAL OF NATURAL PRODUCTS,2006,69(2):234-239. |
APA | Li, N.,Wu, JL.,Hasegawa, T.,Sakai, J.,Wang, LY.,...&Ando, M.(2006).Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.JOURNAL OF NATURAL PRODUCTS,69(2),234-239. |
MLA | Li, N,et al."Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii".JOURNAL OF NATURAL PRODUCTS 69.2(2006):234-239. |
入库方式: OAI收割
来源:上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。