New Guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica
文献类型：期刊论文
| 作者 | Chen, WL; Liu, QF ; Wang, J; Zou, J; Meng, DH; Zuo, JP; Zhu, XZ; Zhao, WM
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| 刊名 | PLANTA MEDICA
 |
| 出版日期 | 2006-02 |
| 卷号 | 72期号:2页码:143-150 |
| 关键词 | Youngia japonica Asteraceae sesquiterpenoid immunosuppressive activity anti-inflammatory activity |
| ISSN号 | 0032-0943 |
| DOI | 10.1055/s-2005-916182 |
| 文献子类 | Article |
| 英文摘要 | Eleven sesquiterpenoids have been isolated from the whole plants of Youngia japonica (Asteraceae). Among these sesquiterpenoids, five were identified as new compounds On the basis of spectroscopic methods and chemical analysis. Their Structures were 3-oxo-8a-(4-liydoxyplienyl)acetoxy-10(14),11(13)-guaiadien-12,6-olide (1), 3 beta-[3-(4-hydroxyphenyl)acetyl-beta-D-gluco-pyranosyloxy]-8 alpha-hydroxy-4(15),10(14),11(13)-guaiatrien-12,6- olide (2), 3 beta-[3-(4-hydroxyphenyl)acetyl-beta-D-glucopyranosyl-oxy]-4(15),10(14),11(13)-guaiatrien-12,6-olide (3), 3 alpha,5 beta,6 alpha-tri-hydroxy-4 alpha-(beta-D-glucopyranosyloxy)-7-megastigmem-9-one (4), and 3 alpha-(beta-D-glucopyranosyloxy)-4(15),11(13)-eudesmadien-12-oic acid (5). The three known components 3 beta-(beta-D-glucopyranosyloxy)-8 alpha-(4-hydroxyphenyl)acetoxy-4(15),10(14),11(13)-guaiatrien-12,6-olide (8), 3 beta-(beta-D-glucopyranosyloxy)-4(15),10(14),11 (13)-guaiatrien-12,6-olide (9), and 3 alpha-hydroxy-4 alpha-(beta-D-glucopyranosyloxy)-5,7-megastigmadien-9-one (11) showed inhibitory activity against the proliferation of T and B lymphocytes of mice in vitro at concentrations of I X 10(-7), 1 X 10(-6), and/or I X 10(-5) M without obvious cytotoxicity. Compound 9, the major component of the plant extract, exhibited weak anti-inflammatory activity at a dosage of 50 mg/kg (p.o.) in in vivo anti-inflammatory experiments of mice. |
| WOS关键词 | LACTONES ; GLYCOSIDES |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000235565300008 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273682]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, WM |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, WL,Liu, QF,Wang, J,et al. New Guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica[J]. PLANTA MEDICA,2006,72(2):143-150. |
| APA | Chen, WL.,Liu, QF.,Wang, J.,Zou, J.,Meng, DH.,...&Zhao, WM.(2006).New Guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica.PLANTA MEDICA,72(2),143-150. |
| MLA | Chen, WL,et al."New Guaiane, megastigmane and eudesmane-type sesquiterpenoids and anti-inflammatory constituents from Youngia japonica".PLANTA MEDICA 72.2(2006):143-150. |
入库方式： OAI收割
来源：上海药物研究所
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