Screening for in vivo metabolites of isovalertatin family oligosaccharides in rats by liquid chromatography coupled to electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Si, Duanyun; Zhong, Dafang ; Liu, Changxiao
|
| 刊名 | RAPID COMMUNICATIONS IN MASS SPECTROMETRY
 |
| 出版日期 | 2006 |
| 卷号 | 20期号:22页码:3385-3392 |
| ISSN号 | 0951-4198 |
| DOI | 10.1002/rcm.2750 |
| 文献子类 | Article |
| 英文摘要 | Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/MSn) was used to identify trace levels of in vivo metabolites after the administration of isovalertatin M23 or isovalertatin D23 to rats. The biosamples of urine, feces, and ileum incubation were pre-treated by solid-phase extraction (SPE), and then chromatographed with a reversed-phase C-8 column with acetonitrile/1.5mM aqueous ammonia (18:82, v/v) as the mobile solvent. The parent drug and the possible metabolites were identified by two independent qualitative parameters, retention time and collision-induced dissociation product ions. Nine and seven metabolites were successfully characterized from biosamples after administration of isovalertatins M23 and D23, respectively, to rats. The metabolism seemed to take place in the rat intestinal tract, and metabolic pathways were identified including isovaleryl de-esterification and hydrolysis of alpha-glucose units located either at the reducing or the non-reducing terminus. Copyright (c) 2006 John Wiley & Sons, Ltd. |
| WOS关键词 | STREPTOMYCES-LUTEOGRISEUS ; STRUCTURAL REVISION ; CULTURE ; SYSTEMS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000242168900018 |
| 出版者 | JOHN WILEY & SONS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273751]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Si, Duanyun |
| 作者单位 | 1.Tianjin Inst Pharmaceut Res, Tianjin State Key Lab Pharmacokinet & Pharmacodyn, Tianjin 300193, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Metab, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Si, Duanyun,Zhong, Dafang,Liu, Changxiao. Screening for in vivo metabolites of isovalertatin family oligosaccharides in rats by liquid chromatography coupled to electrospray ionization tandem mass spectrometry[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2006,20(22):3385-3392. |
| APA | Si, Duanyun,Zhong, Dafang,&Liu, Changxiao.(2006).Screening for in vivo metabolites of isovalertatin family oligosaccharides in rats by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,20(22),3385-3392. |
| MLA | Si, Duanyun,et al."Screening for in vivo metabolites of isovalertatin family oligosaccharides in rats by liquid chromatography coupled to electrospray ionization tandem mass spectrometry".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 20.22(2006):3385-3392. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。