Synthesis and antitumor activity of novel 2-(thymin-1 '-ylmethoxy)ethyl alkyl sulfides and their oxidation products
文献类型：期刊论文
| 作者 | Liu, XJ; Chen, RY; Bai, DL
|
| 刊名 | PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
 |
| 出版日期 | 2005-12 |
| 卷号 | 180期号:12页码:2607-2616 |
| 关键词 | diethyl azodicarboxylate sulfides sulfones sulfoxides thymine |
| ISSN号 | 1042-6507 |
| DOI | 10.1080/104265090930353 |
| 文献子类 | Article |
| 英文摘要 | A series of novel 2-(thymin-1'-ylmethoxy)ethyl alleyl sulfides have been synthesized in three steps from thymine. They have been oxidized into sulfoxide and sulfone derivatives by means of NalO(4) and H2O2 30%/diethyl azodicarboxylate (DEAD), respectively, in high yields. All products were characterized by (HNMR)-H-1 and IR spectra and elemental analyses. The preliminary bioassay indicates that the compound 6g exhibited potential antitumor activity. |
| WOS关键词 | MODIFIED NUCLEOSIDES ; THYMINE GROUP ; URACIL |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000234212900001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273768]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, XJ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Nankai Univ, Tianjin 300071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, XJ,Chen, RY,Bai, DL. Synthesis and antitumor activity of novel 2-(thymin-1 '-ylmethoxy)ethyl alkyl sulfides and their oxidation products[J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,2005,180(12):2607-2616. |
| APA | Liu, XJ,Chen, RY,&Bai, DL.(2005).Synthesis and antitumor activity of novel 2-(thymin-1 '-ylmethoxy)ethyl alkyl sulfides and their oxidation products.PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS,180(12),2607-2616. |
| MLA | Liu, XJ,et al."Synthesis and antitumor activity of novel 2-(thymin-1 '-ylmethoxy)ethyl alkyl sulfides and their oxidation products".PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS 180.12(2005):2607-2616. |
入库方式： OAI收割
来源：上海药物研究所
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