Semisynthesis and antitumor activities of new styryl-lactone derivatives
文献类型：期刊论文
| 作者 | Zhou, FS; Tang, WD; Mu, Q; Yang, GX; Wang, Y; Liang, GL; Lou, LG
|
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2005-11 |
| 卷号 | 53期号:11页码:1387-1391 |
| 关键词 | styryl-lactone semisynthesis goniothalamin antitumor activity |
| ISSN号 | 0009-2363 |
| DOI | 10.1248/cpb.53.1387 |
| 文献子类 | Article |
| 英文摘要 | Nineteen new derivatives (2-20) of the naturally occurring compound, goniothalamin (1), were prepared by chemical modification and semi-synthetic methods. The antitumor activities of these derivatives and goniothalamin were evaluated in vitro against human tumor cell lines, and most of them showed an inhibitory effect against HL-60 cancer cells. The derivatives 10-nitro-goniothalamin (2) and 10-amino-goniothalamin (4) gave selective inhibition concentration (IC50) of 1.10 and 1.14 mu g/ml, respectively, against human stomach cancer SGC-7901 cells, while that of etoposide (vp-16) as the positive control was 6.07 mu g/ml. Finally, the partition coefficients, logP (pi values), of these derivative molecules, were evaluated by calculating the additive approximate organic fragment logP value. |
| WOS关键词 | GONIOTHALAMIN ; ANNONACEAE |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000233350600002 |
| 出版者 | PHARMACEUTICAL SOC JAPAN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273779]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Mu, Q |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China 2.Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, FS,Tang, WD,Mu, Q,et al. Semisynthesis and antitumor activities of new styryl-lactone derivatives[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2005,53(11):1387-1391. |
| APA | Zhou, FS.,Tang, WD.,Mu, Q.,Yang, GX.,Wang, Y.,...&Lou, LG.(2005).Semisynthesis and antitumor activities of new styryl-lactone derivatives.CHEMICAL & PHARMACEUTICAL BULLETIN,53(11),1387-1391. |
| MLA | Zhou, FS,et al."Semisynthesis and antitumor activities of new styryl-lactone derivatives".CHEMICAL & PHARMACEUTICAL BULLETIN 53.11(2005):1387-1391. |
入库方式： OAI收割
来源：上海药物研究所
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