Bioactive tetrahydrofuran lignans from Peperomia dindygulensis
文献类型：期刊论文
| 作者 | Wu, JL; Li, N; Hasegawa, T; Sakai, J; Kakuta, S; Tang, WX; Oka, S; Kiuchi, M; Ogura, H; Kataoka, T |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2005-11 |
| 卷号 | 68期号:11页码:1656-1660 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np050283e |
| 文献子类 | Article |
| 英文摘要 | Five new tetrahydrofaran lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 mu g/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments. |
| WOS关键词 | RESISTANCE |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000233788200016 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273785]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, N |
| 作者单位 | 1.Tokyo Inst Technol, Ctr Biol Resources & Informat, Midori Ku, Yokohama, Kanagawa 2268501, Japan 2.Univ Tokyo, Inst Mol & Cellular Biol, Tokyo 1130032, Japan 3.Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Div Genome Res, Koto Ku, Tokyo 1358550, Japan 4.Niigata Univ, Dept Chem & Chem Engn, Niigata 9502181, Japan 5.Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan 6.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 7.Hokkaido Univ, Ctr Instrumental Anal, Kita Ku, Sapporo, Hokkaido 0600812, Japan |
| 推荐引用方式 GB/T 7714 | Wu, JL,Li, N,Hasegawa, T,et al. Bioactive tetrahydrofuran lignans from Peperomia dindygulensis[J]. JOURNAL OF NATURAL PRODUCTS,2005,68(11):1656-1660. |
| APA | Wu, JL.,Li, N.,Hasegawa, T.,Sakai, J.,Kakuta, S.,...&Ando, M.(2005).Bioactive tetrahydrofuran lignans from Peperomia dindygulensis.JOURNAL OF NATURAL PRODUCTS,68(11),1656-1660. |
| MLA | Wu, JL,et al."Bioactive tetrahydrofuran lignans from Peperomia dindygulensis".JOURNAL OF NATURAL PRODUCTS 68.11(2005):1656-1660. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。