A clinically relevant orthotopic implantation nude mouse model of human epithelial ovarian cancer-based on consecutive observation
文献类型：期刊论文
| 作者 | Yi, XF; Yuan, ST; Lu, LJ; Ding, J ; Feng, YJ
|
| 刊名 | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
 |
| 出版日期 | 2005-09 |
| 卷号 | 15期号:5页码:850-855 |
| 关键词 | nude mouse orthotopic implantation ovarian neoplasms |
| ISSN号 | 1048-891X |
| DOI | 10.1111/j.1525-1438.2005.00147.x |
| 文献子类 | Article |
| 英文摘要 | The aim of this study is to establish an orthotopic implantation nude mouse model of epithelial ovarian cancer (EOC) and observe its biologic features. A human ovarian tumor line SKOV3ipl previously grown subcutaneously was implanted orthotopically as intact tissue into the ovarian capsule of 64 nude mice. Every week eight mice were taken randomly, and the tumor growth pattern and extent of metastatic disease were monitored continuously. Those mice that died of disease were necropsied and the end date was recorded. The orthotopic implanted tumors demonstrated a 100% take rate. Three weeks after implantation the tumors grew fast and weighed 1149 +/- 152 mg, and 5 weeks after implantation the tumors reached a flat stage. The tumors metastasized more often to peritoneum (32/56) and diaphragm (18/56), then to pelvic lymph nodes (11/56) and lung (10/56), and then to the seldom invaded organs including the pancreas, the liver, the contralateral ovary, and the para-aortic lymph node. Eight nude mice became exhausted 7 weeks after implantation and died within 68 days after implantation. Our study, utilizing the SKOV3ipl cell, is the first model of consecutive observation of the process of invasion and metastasis of EOC. It should be useful in understanding the molecular biology of EOC and in the development of therapeutic modalities against metastasis. |
| WOS关键词 | INTACT PATIENT SPECIMENS ; CARCINOMA-CELLS ; MICE ; METASTASIS ; COLON ; LUNG ; INTRAPULMONARY ; PROPAGATION ; PROGRESSION ; THERAPY |
| WOS研究方向 | Oncology ; Obstetrics & Gynecology |
| 语种 | 英语 |
| WOS记录号 | WOS:000231798800022 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273809]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yi, XF |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Fudan Univ, Dept Gynecol Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, XF,Yuan, ST,Lu, LJ,et al. A clinically relevant orthotopic implantation nude mouse model of human epithelial ovarian cancer-based on consecutive observation[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2005,15(5):850-855. |
| APA | Yi, XF,Yuan, ST,Lu, LJ,Ding, J,&Feng, YJ.(2005).A clinically relevant orthotopic implantation nude mouse model of human epithelial ovarian cancer-based on consecutive observation.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,15(5),850-855. |
| MLA | Yi, XF,et al."A clinically relevant orthotopic implantation nude mouse model of human epithelial ovarian cancer-based on consecutive observation".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 15.5(2005):850-855. |
入库方式： OAI收割
来源：上海药物研究所
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