A novel immunostimulator, N-2-[(alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N-6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen
文献类型：期刊论文
| 作者 | Yang, HZ; Xu, S; Liao, XY; Zhang, SD; Liang, ZL; Liu, BH; Bai, JY; Jiang, C; Ding, J ; Cheng, GF
|
| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2005-08-11 |
| 卷号 | 48期号:16页码:5112-5122 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm0493313 |
| 文献子类 | Article |
| 英文摘要 | N-2-[(alpha-O-Benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl)]-AT6-trans-(m-nitrocinnamoyl)-L-lysine (muramyl dipeptide C, or MDP-C) has been synthesized as a novel, nonspecific immunomodulator. The present study shows that MDP-C induces strong cytolytic activity by macrophages on P388 leukemia cells and cytotoxic activity by cytotoxic T lymphocytes (CTLs) on P815 mastocytoma cells. Our results also indicate that MDP-C is an effective stimulator for production of interleukin-2 and interleukin-12 by murine bone morrow derived dendritic cells (BMDCs) and production of interferon-gamma by CTLs. Additionally, MDP-C increases the expression levels of several surface molecules, including CD11c, MHC class I, and intercellular adhesion molecule-1 in BMDCs. Moreover, MDP-C remarkably enhances the immune system's responsiveness to hepatitis B surface antigen (HBsAg) in hepatitis B virus transgenic mice for both antibody production and specific HBsAg T-cell responses ex vivo. Our results indicate that MDP-C is an apyrogenic, nonallergenic, and low-toxicity immunostimulator with great potential for diagnostic, immunotherapeutic, and prophylactic applications in diseases such as hepatitis B and cancers. |
| WOS关键词 | SOLID-PHASE SYNTHESIS ; SYNTHETIC IMMUNOMODULATOR MURABUTIDE/ ; MURAMYL DIPEPTIDE ANALOGS ; T-LYMPHOCYTE RESPONSES ; DENDRITIC CELLS ; NONSPECIFIC RESISTANCE ; MICROBIAL INFECTIONS ; CLINICAL TOLERANCE ; ANTITUMOR IMMUNITY ; CANCER METASTASIS |
| 资助项目 | NIAID NIH HHS[U01 AI 61092-01] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000231055300008 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273819]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cheng, GF |
| 作者单位 | 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 2.Peking Union Med Coll, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, HZ,Xu, S,Liao, XY,et al. A novel immunostimulator, N-2-[(alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N-6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen[J]. JOURNAL OF MEDICINAL CHEMISTRY,2005,48(16):5112-5122. |
| APA | Yang, HZ.,Xu, S.,Liao, XY.,Zhang, SD.,Liang, ZL.,...&Liu, G.(2005).A novel immunostimulator, N-2-[(alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N-6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen.JOURNAL OF MEDICINAL CHEMISTRY,48(16),5112-5122. |
| MLA | Yang, HZ,et al."A novel immunostimulator, N-2-[(alpha-O-benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl]-N-6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen".JOURNAL OF MEDICINAL CHEMISTRY 48.16(2005):5112-5122. |
入库方式： OAI收割
来源：上海药物研究所
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