Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines
文献类型：期刊论文
| 作者 | Ding, HX; Lu, W; Li, HB; Yang, LX; Zhang, QJ; Zhou, CX; Wu, XM; Baudoin, O; Cai, JC; Francoise, G |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2005 |
| 卷号 | 2期号:9页码:1217-1231 |
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.200590092 |
| 文献子类 | Article |
| 英文摘要 | Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10(-6) M scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. |
| WOS关键词 | TOPOISOMERASE-II INHIBITOR ; PODOPHYLLOTOXIN ANALOGS ; ANTITUMOR AGENTS ; DERIVATIVES ; CYTOTOXICITY ; ETOPOSIDE ; AZATOXIN ; PROTEINS ; DESIGN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000232226900009 |
| 出版者 | VERLAG HELVETICA CHIMICA ACTA AG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273949]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Y |
| 作者单位 | 1.Zhejiang Hisun Naturelite Pharmaceut R&D Co Ltd, Hangzhou 310006, Peoples R China 2.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, SIBS, Shanghai 201203, Peoples R China 4.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France |
| 推荐引用方式 GB/T 7714 | Ding, HX,Lu, W,Li, HB,et al. Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines[J]. CHEMISTRY & BIODIVERSITY,2005,2(9):1217-1231. |
| APA | Ding, HX.,Lu, W.,Li, HB.,Yang, LX.,Zhang, QJ.,...&Zhao, Y.(2005).Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines.CHEMISTRY & BIODIVERSITY,2(9),1217-1231. |
| MLA | Ding, HX,et al."Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines".CHEMISTRY & BIODIVERSITY 2.9(2005):1217-1231. |
入库方式： OAI收割
来源：上海药物研究所
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