Establishment of a subcutaneous model of the human extrahepatic bile duct carcinoma in nude mice via transplantation of histologically intact tumor tissue
文献类型：期刊论文
| 作者 | Tang, WH; Yuan, ST; Wang, BS; Lu, LJ; Ding, J ; Yuan, ZR
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| 刊名 | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
 |
| 出版日期 | 2004-12 |
| 卷号 | 23期号:4页码:661-667 |
| ISSN号 | 0392-9078 |
| 关键词 | nude mice bile duct carcinoma transplanted tumor model |
| 文献子类 | Article |
| 英文摘要 | The purpose of the study was to establish the subcutaneous model of human extrahepatic bile duct carcinoma in nude mice so as to provide a suitable model for the study of extrahepatic bile duct carcinoma. Surgical specimens of the patient with extrahepatic bile duct carcinoma were transplanted into the subcutaneous layer of nude mice. Growth curve of transplanted tumors was drawn and its morphological and biological characteristics. as well as choromosome were observed. A well differentiated mucinous adenocarcinoma model of human bile duct carcinoma in nude mice, designated as HBDCM1-ZSH (Human Bile Duct Carcinoma Model No. 1 established by Zhong Shan Hospital in April, 2001), was established via subcutaneous transplantation of the surgically resected tumor from a 56-year-old Chinese man. HBDCM1-ZSH has been maintained for 13 passages and exhibited 98.1% transplantability. Mean latent periods were 26 days. Transplanted tumors exhibited the characteristics of the original tumor in morphology and biology. Chromosomal analysis revealed numerical abnormalities ranging from 67 to 84. HBDCM1-ZSH expressed carcinoembryonic antigen (CEA), carbohydrate antigen (CA)19-9. cytokeratin (CK7, CK19, CK20), PCNA, AB and PAS. In conclusion. HBDCM1-ZSH is similar to human extrahepatic bile duct carcinoma and provides an applicable animal model for research on extrahepatic bile duct carcinoma. |
| WOS关键词 | HUMAN CANCER METASTASIS ; CELL-LINE ; BIOLOGY |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | APSIT ASSOC PROM STUD IMMUNOL TUMOR |
| WOS记录号 | WOS:000226497300015 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/273988]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tang, WH |
| 作者单位 | 1.Hua Dong Hosp, Dept Gen Surg, Shanghai, Peoples R China 2.Fudan Univ, Zhong Shan Hosp, Dept Gen Surg, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, WH,Yuan, ST,Wang, BS,et al. Establishment of a subcutaneous model of the human extrahepatic bile duct carcinoma in nude mice via transplantation of histologically intact tumor tissue[J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2004,23(4):661-667. |
| APA | Tang, WH,Yuan, ST,Wang, BS,Lu, LJ,Ding, J,&Yuan, ZR.(2004).Establishment of a subcutaneous model of the human extrahepatic bile duct carcinoma in nude mice via transplantation of histologically intact tumor tissue.JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,23(4),661-667. |
| MLA | Tang, WH,et al."Establishment of a subcutaneous model of the human extrahepatic bile duct carcinoma in nude mice via transplantation of histologically intact tumor tissue".JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 23.4(2004):661-667. |
入库方式： OAI收割
来源：上海药物研究所
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