Novel cytotoxic copper(II) complexes of 8-aminoquinoline derivatives: Crystal structure and different reactivity towards glutathione
文献类型：期刊论文
| 作者 | Zhang, SC; Tu, C; Wang, XY; Yang, Z; Zhang, JY; Lin, LP; Ding, J ; Guo, ZJ
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| 刊名 | EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
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| 出版日期 | 2004-10-18 |
| 期号 | 20页码:4028-4035 |
| 关键词 | antitumor agents bioinorganic chemistry copper N ligands |
| ISSN号 | 1434-1948 |
| DOI | 10.1002/ejic.200400357 |
| 文献子类 | Article |
| 英文摘要 | Two novel Cu-11 complexes [Cu(CMQA)(H2O)] (1) (CMQA = N-carboxymethyl-L-methionine-N'-8-quinolylamide) and [Cu(MQA)(OAc)] (2) (MQA = L-methionine-N'-8-quinolylamide, OAc = CH3COO-) have been synthesized and structurally characterized. Complex 1 crystallizes in the orthorhombic system with space group P2(1)2(1)2(1) [a = 5.556(l) Angstrom, b = 15.002(3) Angstrom, c = 20.886(4) Angstrom] while complex 2 crystallizes in the monoclinic system with space group C2 [a = 28.463(6) A, b = 5.264(1) Angstrom, c = 13.345(3) Angstrom, beta = 109.142(3)degrees]. In both complexes the Cu-11 center is coordinated by three N atoms of the ligand and one 0 atom of H2O (1) or OAc (2). The in vitro cytotoxicity of both complexes and their corresponding ligands have been tested against the murine leukemia P-388 and lung adenocarcinoma A-549 cell lines. Complex 2 shows a potent activity against both cell lines with an inhibitory rate of 100% for the murine leukemia P-388 cell line and 93.4% for the lung adenocarcinoma A-549 cell line at a concentration of 10(-6) mol(.)L(-1), while complex 1 shows only a marginal activity against the same cell lines. The reactivity of the two complexes towards gamma-glutathione (GSH) has been investigated and is discussed in association with their different cytotoxicity. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004) |
| WOS关键词 | OVARIAN-CARCINOMA CELLS ; L1210 MURINE LEUKEMIA ; ANTITUMOR-ACTIVITY ; TOXICITY ; LIGAND ; DNA ; THIOSEMICARBAZONE ; METALLOTHIONEINS ; MEDICINE ; ADDUCTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000225781600009 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274004]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, ZJ |
| 作者单位 | 1.Nanjing Univ, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China 2.Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Div Anti Tumor Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, SC,Tu, C,Wang, XY,et al. Novel cytotoxic copper(II) complexes of 8-aminoquinoline derivatives: Crystal structure and different reactivity towards glutathione[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,2004(20):4028-4035. |
| APA | Zhang, SC.,Tu, C.,Wang, XY.,Yang, Z.,Zhang, JY.,...&Guo, ZJ.(2004).Novel cytotoxic copper(II) complexes of 8-aminoquinoline derivatives: Crystal structure and different reactivity towards glutathione.EUROPEAN JOURNAL OF INORGANIC CHEMISTRY(20),4028-4035. |
| MLA | Zhang, SC,et al."Novel cytotoxic copper(II) complexes of 8-aminoquinoline derivatives: Crystal structure and different reactivity towards glutathione".EUROPEAN JOURNAL OF INORGANIC CHEMISTRY .20(2004):4028-4035. |
入库方式： OAI收割
来源：上海药物研究所
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