Effect of anti-cancer drugs on the binding of I-125-fibrinogen to two leukaemia cell lines in vitro
文献类型：期刊论文
| 作者 | Lu, D; Chi, J; Lin, LP; Huang, M ; Xu, B; Ding, J
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| 刊名 | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
 |
| 出版日期 | 2004-09 |
| 卷号 | 32期号:5页码:488-491 |
| 关键词 | fibrinogen metastasis anti-neoplastic agents anti-coagulant probimane |
| ISSN号 | 0300-0605 |
| DOI | 10.1177/147323000403200505 |
| 文献子类 | Article |
| 英文摘要 | Anti-cancer drugs may be able to inhibit tumour growth and metastasis by blocking fibrinogen- and/or fibrin-related pathways. To test this hypothesis, the effect of various anti-neoplastic drugs on the binding of I-125-Fibrinogen to two leukaemia cell lines, HL60 and P388, was investigated. All the drugs tested inhibited the binding of fibrinogen to leukaemia cells. This effect was particularly marked for drugs that act as inhibitors of protein synthesis. Since these anti-neoplastic drugs do not have anti-coagulant actions, these results provide evidence for the potential of targeting tumour fibrinogen as a new form of cancer chemotherapy. |
| WOS关键词 | FIBRIN ; ANGIOGENESIS ; METASTASIS ; CANCER |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000223813000005 |
| 出版者 | CAMBRIDGE MED PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274025]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, D |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, D,Chi, J,Lin, LP,et al. Effect of anti-cancer drugs on the binding of I-125-fibrinogen to two leukaemia cell lines in vitro[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2004,32(5):488-491. |
| APA | Lu, D,Chi, J,Lin, LP,Huang, M,Xu, B,&Ding, J.(2004).Effect of anti-cancer drugs on the binding of I-125-fibrinogen to two leukaemia cell lines in vitro.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,32(5),488-491. |
| MLA | Lu, D,et al."Effect of anti-cancer drugs on the binding of I-125-fibrinogen to two leukaemia cell lines in vitro".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 32.5(2004):488-491. |
入库方式： OAI收割
来源：上海药物研究所
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