Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway
文献类型：期刊论文
| 作者 | Lai, C; Feng, LY
|
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2004-06-25 |
| 卷号 | 319期号:2页码:603-611 |
| 关键词 | neural progenitor cell neuregulin proliferation PLC PKQ TPA |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2004.05.027 |
| 文献子类 | Article |
| 英文摘要 | Nestin-expressing neural progenitor cells (NPCs) have been isolated from hippocampus of brains and propagated with epidermal growth factor and basic fibroblast growth factor (bFGF). However, the underlying signaling mechanisms regulating NPC proliferation remain elusive. Here we showed that neuregulinbeta1 (NRG), like bFGF, effectively promoted the proliferation of hippocampus-derived NPCs and maintained the progenitor states of NPCs. Activation of protein kinase C (PKC), a downstream effector of phospholipase C (PLC), with 12-O-tetradecanoylphorbol-13-acetate (TPA) mimicked the NRG-induced proliferation of NPCs. The synergic effect of TPA plus NRG on neurosphere growth further prompted us to find that NRG induced NPC propagation through PLC/PKC signaling pathway. ErbB4, an important functional receptor of NRG, had an interaction with PLCgamma1 protein. In addition, inactivation of PLC pathway led to severe proliferative suppression of NPCs. Our study suggests that activation of PLC/PKC pathway plays an essential role in the NRG-induced proliferation of hippocampus-derived NPCs. (C) 2004 Elsevier Inc. All rights reserved. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; FIBROBLAST-GROWTH-FACTOR ; STEM-CELLS ; NEUROTROPHIC FACTOR ; PHOSPHOLIPASE-C ; CORTICAL-NEURONS ; EPITHELIAL-CELLS ; PRECURSOR CELLS ; CANCER CELLS ; MAP KINASE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000222062700043 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274058]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Feng, LY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, C,Feng, LY. Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,319(2):603-611. |
| APA | Lai, C,&Feng, LY.(2004).Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,319(2),603-611. |
| MLA | Lai, C,et al."Neuregulin induces proliferation of neural progenitor cells via PLC/PKC pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 319.2(2004):603-611. |
入库方式： OAI收割
来源：上海药物研究所
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