General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice
文献类型：期刊论文
| 作者 | Guo, QL; You, QD; Wu, ZQ; Yuan, ST; Zhao, L |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2004-06 |
| 卷号 | 25期号:6页码:769-774 |
| 关键词 | gamboge gambogic acid hepatoma SMMC-7721 cells telomerase nude mice |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the inhibitory effect of general gambogic acids (GGA) on transplantation tumor SMMC-7721 in experimental animal model and SMMC-7721 cells in vitro. METHODS: Anti-tumor activity of GGA in the experimental transplantation tumor SMMC-7721 was evaluated by relative tumor growth ratio. Cell morphology was observed with inverted microscope and electron microscope. Cell proliferation was measured by MTT assay and the telomerase activity was determined by PCR. RESULTS: In vivo study indicated that GGA (2, 4, and 8 mg/kg, iv, 3 times per week for 3 weeks) displayed an inhibitory effect on the growth of transplantation tumor SMMC-7721 in nude mice compared with the normal saline group (P<0.01). At the concentrations of 0.625-5.0 mg/L, GGA remarkably inhibited the proliferation of SMMC-7721 cells in vitro. GGA 2 mg/L dramatically changed morphology of SMMC-7721 cells and inhibited the telomerase activity in SMMC-7721 cells. CONCLUSION: GGA had inhibitory effect on the growth of SMMC-7721, which might be related to its inhibition of telomerase activity. |
| WOS关键词 | HUMAN TELOMERASE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000221833900011 |
| 出版者 | SHANGHAI INST MATERIA MEDICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274065]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, QL |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst BIol Sci, Inst Mat Med, Shanghai 200031, Peoples R China 2.China Pharmaceut Univ, Dept Physiol, Nanjing 210009, Peoples R China 3.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, QL,You, QD,Wu, ZQ,et al. General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice[J]. ACTA PHARMACOLOGICA SINICA,2004,25(6):769-774. |
| APA | Guo, QL,You, QD,Wu, ZQ,Yuan, ST,&Zhao, L.(2004).General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice.ACTA PHARMACOLOGICA SINICA,25(6),769-774. |
| MLA | Guo, QL,et al."General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice".ACTA PHARMACOLOGICA SINICA 25.6(2004):769-774. |
入库方式： OAI收割
来源：上海药物研究所
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