Syntheses of 2-or 6-substituted chromones and chromone ring-opening reaction in polyphosphoric acid
文献类型：期刊论文
| 作者 | He, XG; You, QD; Li, ZY |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2004-05 |
| 卷号 | 20期号:3页码:299-304 |
| 关键词 | 2-or 6-substituted chromone antitumor agent polyphosphoric acid ring-opening reaction |
| ISSN号 | 1005-9040 |
| 文献子类 | Article |
| 英文摘要 | In an attempt to find new antitumor agents, a novel class of chromone compounds with a benzimidazole or a benzoxazole ring in positions 2 or 6 were synthesized via condensation in polyphosphoric acid(PPA) by using chromone acids as the starting materials. During the preparation process, it was found that PPA could cleave the chromone ring to produce a ring-opening compound(6). The molar ratio of the chromone compound(5) to the ring-opening compound(6) varied with the change of reaction temperature and time. Based on MTT protocol, the antitumor activity of each of the compounds obtained was evaluated against three human cancer cell lines: KB (oral epidermal), A2780 (ovary) and Bel7402 (liver). The IC50 varied from 54.7 mumol/L to more than 180 mumol/L. |
| WOS关键词 | ANTIMICROBIAL ACTIVITY ; INVITRO |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000221972300012 |
| 出版者 | HIGHER EDUCATION PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274084]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | You, QD |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, XG,You, QD,Li, ZY. Syntheses of 2-or 6-substituted chromones and chromone ring-opening reaction in polyphosphoric acid[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2004,20(3):299-304. |
| APA | He, XG,You, QD,&Li, ZY.(2004).Syntheses of 2-or 6-substituted chromones and chromone ring-opening reaction in polyphosphoric acid.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,20(3),299-304. |
| MLA | He, XG,et al."Syntheses of 2-or 6-substituted chromones and chromone ring-opening reaction in polyphosphoric acid".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 20.3(2004):299-304. |
入库方式： OAI收割
来源：上海药物研究所
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