Identification of genes responsive to apoptosis in HL-60 cells
文献类型：期刊论文
| 作者 | Jin, W; Qu, LF; Min, P; Chen, S; Hong, L; Lu, H; Hou, YT |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2004-03 |
| 卷号 | 25期号:3页码:319-326 |
| 关键词 | HL-60 cells homoharringtonine apoptosis oligonucleotide array sequence analysis gene expression |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To identify genes responsive to apoptosis in HL-60 cells treated by homoharringtonine. METHODS: cDNA microarray technology was used to detect gene expression and the result of microarrays for genes (TIEG and VDUP1) was confirmed by Northern analysis. RESULTS: Seventy-five individual mRNAs whose mass changed significantly were identified. Among these genes (25 were up-regulated and 50 were down-regulated), most are known related to oncogenes and tumor suppressor. Some genes were involved in apoptosis signaling pathways. CONCLUSION: TGFbeta and TNF apoptosis signaling pathways were initiated during apoptosis in HL-60 cells. TIEG and VDUP1 play important roles in mediating apoptosis. |
| WOS关键词 | CHROMOSOMAL LOCALIZATION ; TRANSCRIPTION FACTOR ; MOLECULAR-CLONING ; OXIDATIVE STRESS ; BINDING PROTEIN ; KAPPA-B ; EXPRESSION ; PHOSPHATASE ; SUBUNIT ; CANCER |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1844996 |
| WOS记录号 | WOS:000220117800012 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274106]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hou, YT |
| 作者单位 | 1.Chianghai Hosp, Dept Vasc Surg, Shanghai 200433, Peoples R China 2.Ruijin Hosp, Le Pole Franco Chinois Sci Vivant & Genom, Shanghai 200025, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Chianghai Hosp, Inst Vasc Surg PLA, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, W,Qu, LF,Min, P,et al. Identification of genes responsive to apoptosis in HL-60 cells[J]. ACTA PHARMACOLOGICA SINICA,2004,25(3):319-326. |
| APA | Jin, W.,Qu, LF.,Min, P.,Chen, S.,Hong, L.,...&Hou, YT.(2004).Identification of genes responsive to apoptosis in HL-60 cells.ACTA PHARMACOLOGICA SINICA,25(3),319-326. |
| MLA | Jin, W,et al."Identification of genes responsive to apoptosis in HL-60 cells".ACTA PHARMACOLOGICA SINICA 25.3(2004):319-326. |
入库方式： OAI收割
来源：上海药物研究所
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