Design and synthesis of dimeric HIV-1 integrase inhibitory peptides
文献类型：期刊论文
| 作者 | Krajewski, K; Long, YQ; Marchand, C; Pommier, Y; Koller, PP |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2003-10-06 |
| 卷号 | 13期号:19页码:3203-3205 |
| ISSN号 | 0960-894X |
| DOI | 10.1016/S0960-894X(03)00679-6 |
| 文献子类 | Article |
| 英文摘要 | Dimers of known HIV-1 integrase inhibitory hexapeptide H-His-Cys-Lys-Phe-Trp-Trp-NH2 containing different lengths of cross linkers in the place of cysteine residue, were designed, and synthesized. The inhibitory potency of these dimeric peptides is consistently higher than the lead hexapeptide. The dimeric peptide with djenkolic acid linker exhibited IC50 values of 5.3 and 6.5 muM, for 3'-end processing and strand transfer, respectively. (C) 2003 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SOLID-PHASE |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000185322500016 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274169]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Koller, PP |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.NCI Frederick, CCR, Med Chem Lab, NIH, Frederick, MD 21702 USA 3.NCI, Mol Pharmacol Lab, CCR, NIH, Bethesda, MD 20892 USA 4.Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland |
| 推荐引用方式 GB/T 7714 | Krajewski, K,Long, YQ,Marchand, C,et al. Design and synthesis of dimeric HIV-1 integrase inhibitory peptides[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2003,13(19):3203-3205. |
| APA | Krajewski, K,Long, YQ,Marchand, C,Pommier, Y,&Koller, PP.(2003).Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,13(19),3203-3205. |
| MLA | Krajewski, K,et al."Design and synthesis of dimeric HIV-1 integrase inhibitory peptides".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13.19(2003):3203-3205. |
入库方式： OAI收割
来源：上海药物研究所
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