Artemisinin derivatives bearing Mannich base group: Synthesis and antimalarial activity
文献类型：期刊论文
| 作者 | Li, Y ; Yang, ZS; Zhang, H; Cao, BJ; Wang, FD; Zhang, Y; Shi, YL; Yang, JD; Wu, BA
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2003-10-01 |
| 卷号 | 11期号:20页码:4363-4368 |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/S0968k-0896(03)00499-1 |
| 文献子类 | Article |
| 英文摘要 | Novel artemisinin derivatives bearing Mannich base group were prepared and tested for their antimalarial activity. These water-soluble artemisinin derivatives were more stable than sodium artesunate and few compounds were found to be more active against Plasmodium berghei in mice than artesunic acid by oral administration. Two most potent derivatives 17b and 17d were examined for their antimalarial activity against Plasmodium knowlesi in rhesus monkeys. (C) 2003 Elsevier Ltd. All rights reserved. |
| WOS关键词 | SOLUBLE DIHYDROARTEMISININ DERIVATIVES ; FALCIPARUM-MALARIA ; PYRONARIDINE ; ANALOGS ; ASSIGNMENTS ; EFFICACY ; H-1 |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000185456200008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274172]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Y |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Synthet Chem, Shanghai 201203, Peoples R China 2.Acad Mil Med Sci, Inst Microbiol & Epidemiol, Dept Malaria, Beijing 100071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Y,Yang, ZS,Zhang, H,et al. Artemisinin derivatives bearing Mannich base group: Synthesis and antimalarial activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2003,11(20):4363-4368. |
| APA | Li, Y.,Yang, ZS.,Zhang, H.,Cao, BJ.,Wang, FD.,...&Wu, BA.(2003).Artemisinin derivatives bearing Mannich base group: Synthesis and antimalarial activity.BIOORGANIC & MEDICINAL CHEMISTRY,11(20),4363-4368. |
| MLA | Li, Y,et al."Artemisinin derivatives bearing Mannich base group: Synthesis and antimalarial activity".BIOORGANIC & MEDICINAL CHEMISTRY 11.20(2003):4363-4368. |
入库方式： OAI收割
来源：上海药物研究所
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