The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response
文献类型：期刊论文
| 作者 | Wu, Y; Wang, YP ; Zhong, CP; Li, YC; Li, XY; Sun, B
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| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2003-10 |
| 卷号 | 3期号:10-11页码:1457-1465 |
| 关键词 | triptolide cyclosporin A experimental autoimmune uveoretinitis Th1-type response suppressive effect |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/S1567-5769(03)00144-9 |
| 文献子类 | Article |
| 英文摘要 | We investigated the suppressive effect of triptolide (TRD), a purified component from a traditional Chinese herb, Tripterygium wilfordii Hook F. (TWHf), on uveitogenic peptide (K2)-induced experimental autoimmune uveoretinitis (EAU). K2-peptide immunized B10.A mice were divided into four groups. One group was EAU control which was treated with PBS. The other two groups were treated with TRD with different time courses (from day 0 to day 28 and from day 14 to day 28). The last group was treated with Cyclosporin A (CsA) as a positive control of the treatment. TRD was administered at dose of 0.1 mg/kg/day (i.p.). CsA was administered at dose of 20 mg/kg/day (i.p.) from day 0 to day 28 during whole period of EAU induction. The data showed that the EAU was suppressed in the whole period of TRD-treated mice, but was not in TRD-treated mice from day 14 to day 28 following immunization. The inhibition of EAU induced by TRD treatment was comparable to CsA-treated mice. The K2-spcific lymphocyte proliferation and mRNA expressions of Th1-type cytokines (IL-12p40, IFN-gamma and TNF-alpha) in draining lymph node and inflamed eyes were reduced in TRD-treated mice. The K2-specific IFN-gamma production in the draining lymph node cells (LNC) of TRD-treated mice (whole period) was significantly inhibited. This effect was not related to an apoptotic effect of TRD on CD4(+) T cells. Our results suggested that TRD suppressed the induction of EAU by down-regulating Th1-type response in B10.A mice. This preventive effect on EAU induction may be related to the inhibition of TRD on T cell priming and activation. (C) 2003 Elsevier B.V All rights reserved. |
| WOS关键词 | WILFORDII HOOK-F ; CYCLOSPORINE-A ; T-LYMPHOCYTE ; MICE ; EXPRESSION ; UVEITIS ; FK506 ; PROLIFERATION ; ARTHRITIS ; DISEASE |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000185426300011 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274177]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Sun, B |
| 作者单位 | 1.Fudan Univ, Sch Med, Dept Anat, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Y,Wang, YP,Zhong, CP,et al. The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2003,3(10-11):1457-1465. |
| APA | Wu, Y,Wang, YP,Zhong, CP,Li, YC,Li, XY,&Sun, B.(2003).The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response.INTERNATIONAL IMMUNOPHARMACOLOGY,3(10-11),1457-1465. |
| MLA | Wu, Y,et al."The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response".INTERNATIONAL IMMUNOPHARMACOLOGY 3.10-11(2003):1457-1465. |
入库方式： OAI收割
来源：上海药物研究所
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