Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5 '-GMP
文献类型：期刊论文
| 作者 | Zhang, JY; Ke, XK; Tu, C; Lin, J; Ding, J ; Lin, LP; Fun, HK; You, XY; Guo, ZJ
|
| 刊名 | BIOMETALS
 |
| 出版日期 | 2003-09 |
| 卷号 | 16期号:3页码:485-496 |
| 关键词 | Cu(II) complexes cytotoxicity X-ray crystal structure 5 '-GMP |
| ISSN号 | 0966-0844 |
| DOI | 10.1023/A:1022577420708 |
| 文献子类 | Article |
| 英文摘要 | Three new ligands, N-(8-quinolyl)pyridine-2-carboxamide (HL1), N-(8-quinolyl) glycine-N'-Boc-carboxamide (HL2), N-(8-quinolyl)-L-alanine-N'-Boc-carboxamide (HL3), and their Cu(II) complexes have been synthesized. Crystallographic data reveal that complex I, [Cu(L-1)(Ac)(H2O)], is penta-coordinated with a square-pyramidal geometry while complexes V [Cu(L-2')(H2O)] and VI [Cu(L-3')(H2O)] are tetra-coordinated to give square planar geometry. In vitro tests showed that the Cu( II) complexes with L-1 (I-IV) exhibited cytotoxicity at a concentration of 10(-8) M against murine leukemia P-388 and human leukemia HL-60 cell lines, which is more potent than cisplatin. However, ligands HL2 and HL3 and their corresponding copper complexes demonstrated very weak in vitro activities towards the cell lines examined. ESMS data shows that complex I binds rapidly with 5'-GMP to form 1:1 and 2:2 adduct. |
| WOS关键词 | COPPER(II) COMPLEXES ; CRYSTAL-STRUCTURE ; ADENOSINE 5'-DIPHOSPHATE ; STACKING INTERACTIONS ; CHEMICAL NUCLEASES ; ANTITUMOR-ACTIVITY ; LIGAND ; DNA ; CHEMISTRY ; METALS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000181234300016 |
| 出版者 | KLUWER ACADEMIC PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274191]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, ZJ |
| 作者单位 | 1.Nanjing Univ, State Key Lab Coordinat Chem, Inst Coordinat Chem, Nanjing 210093, Peoples R China 2.Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, George Town 11800, Malaysia 3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Anti Tumor Pharmacol, State Key Lab New Drug Res,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, JY,Ke, XK,Tu, C,et al. Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5 '-GMP[J]. BIOMETALS,2003,16(3):485-496. |
| APA | Zhang, JY.,Ke, XK.,Tu, C.,Lin, J.,Ding, J.,...&Guo, ZJ.(2003).Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5 '-GMP.BIOMETALS,16(3),485-496. |
| MLA | Zhang, JY,et al."Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5 '-GMP".BIOMETALS 16.3(2003):485-496. |
入库方式： OAI收割
来源：上海药物研究所
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