Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402
文献类型：期刊论文
| 作者 | Zhang, JY; Wang, XY; Tu, C; Lin, J; Ding, J ; Lin, LP; Wang, ZM; He, C; Yan, CH; You, XZ
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| 刊名 | JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2003-07-31 |
| 卷号 | 46期号:16页码:3502-3507 |
| ISSN号 | 0022-2623 |
| DOI | 10.1021/jm020593j |
| 文献子类 | Article |
| 英文摘要 | Three novel Pt(II) complexes [PtL1'Cl] I (L-1' = glycine-N'-8-quinolylamide), [PtL2'CIl]II(L-2' = L-alanine-N'-8-quinolylamide), and [PtL3Cl] III [L-3 = N-(tert-butoxycarbonyl)-L-methionine-wN'-8-quinolylamide] have been synthesized and characterized. The crystal structure of complexes II and III showed that the ligands are three-coordinated with only one Cl- as the leaving group. Complex II crystallized in the monoclinic system with space group P2(1), a = 9.502(2) Angstrom, b = 4.724(1) Angstrom, c = 14.800(3) Angstrom, while complex III crystallized in the orthorhombic system with space group P2(1)2(1)2(1), a = 5.441(1) Angstrom, b = 12.978(3) Angstrom, c = 29.438(6) Angstrom. These complexes have been tested against a wide range of tumor cell lines including BEL-7402, HCT-116, SPC-A4, MOLT-4, P388, HL-60, A-549, SGC-7901, MKN-28, and HO-8910. Complex III is highly cytotoxic against the HCT-116 (IC50 = 0.38 muM), SPC-A4 (IC50 = 0.43 muM), BEL-7402 (IC50 = 0.43 muM), and MOLT-4 (IC50 = 0.61 muM) cell lines. The cell line most sensitive to III is human liver carcinoma cell line BEL-7402, which has a response rate of 75.1% at 6.6 x 10(-7) M, nearly 6 times higher than that of cisplatin. |
| WOS关键词 | ANTITUMOR-ACTIVITY ; DNA-BINDING ; DRUGS ; LIGANDS ; AGENTS ; ASSAY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000184408600012 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274206]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, ZJ |
| 作者单位 | 1.Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Peoples R China 2.Peking Univ, State Key Lab Rare Earth Mat Chem & Appl, Beijing 100871, Peoples R China 3.Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab New Drug Res, Div Antitumor Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, JY,Wang, XY,Tu, C,et al. Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402[J]. JOURNAL OF MEDICINAL CHEMISTRY,2003,46(16):3502-3507. |
| APA | Zhang, JY.,Wang, XY.,Tu, C.,Lin, J.,Ding, J.,...&Guo, ZJ.(2003).Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402.JOURNAL OF MEDICINAL CHEMISTRY,46(16),3502-3507. |
| MLA | Zhang, JY,et al."Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402".JOURNAL OF MEDICINAL CHEMISTRY 46.16(2003):3502-3507. |
入库方式： OAI收割
来源：上海药物研究所
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