Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus
文献类型：期刊论文
| 作者 | Hou, XY; Zhang, GY; Zong, YY |
| 刊名 | NEUROSCIENCE LETTERS
 |
| 出版日期 | 2003-06-05 |
| 卷号 | 343期号:2页码:125-128 |
| 关键词 | brain ischemia postsynaptic density protein 95 N-methyl-D-aspartate receptor Src Fyn tyrosine phosphorylation hippocampus |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/S0304-3940(03)00365-3 |
| 文献子类 | Article |
| 英文摘要 | The effects of suppression of postsynaptic density protein 95 (PSD-95) expression on the increased tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit NR2A and interactions of Src and Fyn with NR2A after brain ischemia were investigated by immunoprecipitation and immunoblotting. Transient (15 min) brain ischemia was induced by the four-vessel occlusion method in Sprague-Dawley rats. Intracerebroventricular infusion of PSD-95 antisense oligonucleotides (every 24 h for 3 days before ischemia), but not missense oligonucleotides or vehicle, not only markedly decreased the protein level of PSD-95 but also attenuated the elevated tyrosine phosphorylation of NR2A and interactions of Src and Fyn with NR2A induced by 6 h of reperfusion following ischemia in the hippocampus. The protein levels of NR2A, Src and Fyn had no differences under the above conditions. These data suggested that PSD-95 is critical for facilitating NR2A tyrosine phosphorylation by Src family kinases in postischemic brain. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved. |
| WOS关键词 | MEDIATED RESPONSES ; CEREBRAL-ISCHEMIA ; NMDA ; PSD-95 ; ACTIVATION ; CHANNELS ; MECHANISMS ; PLASTICITY ; KINASE ; ACID |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000183232800014 |
| 出版者 | ELSEVIER IRELAND LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274221]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, GY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Xuzhou 221002, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, XY,Zhang, GY,Zong, YY. Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus[J]. NEUROSCIENCE LETTERS,2003,343(2):125-128. |
| APA | Hou, XY,Zhang, GY,&Zong, YY.(2003).Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus.NEUROSCIENCE LETTERS,343(2),125-128. |
| MLA | Hou, XY,et al."Suppression of postsynaptic density protein 95 expression attenuates increased tyrosine phosphorylation of NR2A subunits of N-methyl-D-aspartate receptors and interactions of Src and Fyn with NR2A after transient brain ischemia in rat hippocampus".NEUROSCIENCE LETTERS 343.2(2003):125-128. |
入库方式： OAI收割
来源：上海药物研究所
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