Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats
文献类型：期刊论文
| 作者 | Zhang, SC; Wang, W; Ren, WY; Dai, QA; He, BM; Zhou, K |
| 刊名 | CHINESE MEDICAL JOURNAL
 |
| 出版日期 | 2003-05 |
| 卷号 | 116期号:5页码:767-771 |
| 关键词 | bacterial translocation cirrhosis intestinal permeability lactulose endotoxin |
| ISSN号 | 0366-6999 |
| 文献子类 | Article |
| 英文摘要 | Objective To investigate the effects of lactulose on intestinal bacterial overgrowth (IBO), bacterial translocation (BT), intestinal transit and permeability in cirrhotic rats. Methods BT in all animals was assessed by bacterial culture of mesenteric lymph node (MLN), liver and spleen, and IBO was assessed by a jejunal bacterial count of the specific organism. Intestinal permeability was determined by the 24-hour urinary Tc-99m-diethylenetriamine pentaacetatic acid (Tc-99m-DTPA) excretion, and intestinal transit was determined by measuring the distribution of Cr-51 in the intestine. Results BT and IBO were found in 48% and 80% of the cirrhotic rats, respectively, while not in the control rats. Cirrhotic rats with IBO had significantly higher levels of intestinal endotoxin higher rates of bacterial translocation, shorter intestinal transit time and higher intestinal permeability than those without IBO. It was also found that BT were closely associated with IBO and injury of the intestinal barrier. Compared with the placebo group, lactulose-treated rats had lower rates of BT and IBO, which were closely associated with increased intestinal transit and improved intestinal permeability by lactulose. Conclusions Our study indicate that endotoxin and bacterial translocation in cirrhotic rats may attribute to IBO and increased intestinal permeability. Lactulose that accelerates intestinal transit and improves intestinal permeability might be helpful in preventing intestinal bacterial and endotoxin translocation. |
| WOS关键词 | LIVER-CIRRHOSIS ; PERITONITIS ; OVERGROWTH ; DECONTAMINATION ; PERMEABILITY ; NORFLOXACIN ; TRANSIT |
| WOS研究方向 | General & Internal Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000183404400031 |
| 出版者 | CHINESE MEDICAL ASSOCIATION |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274239]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, SC |
| 作者单位 | 1.Chinese Acad Sci, Inst Mat Med, Shanghai 200032, Peoples R China 2.Shanghai Med Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, SC,Wang, W,Ren, WY,et al. Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats[J]. CHINESE MEDICAL JOURNAL,2003,116(5):767-771. |
| APA | Zhang, SC,Wang, W,Ren, WY,Dai, QA,He, BM,&Zhou, K.(2003).Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats.CHINESE MEDICAL JOURNAL,116(5),767-771. |
| MLA | Zhang, SC,et al."Effects of lactulose on intestinal endotoxin and bacterial translocation in cirrhotic rats".CHINESE MEDICAL JOURNAL 116.5(2003):767-771. |
入库方式： OAI收割
来源：上海药物研究所
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