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Caspase-3: a new target for neurodegenerative diseases treatment

文献类型：期刊论文

作者Zhang, YH; Li, J; Zhou, ZL
刊名PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
出版日期2003-04
卷号30期号:2页码:175-179
关键词caspase-3 inhibitors apoptosis neurodegenerative diseases
ISSN号1000-3282
文献子类Article
英文摘要Caspase-3, a member of the caspase family, is the key protein enzyme of mammalian cell in apoptosis. Recent studies show that caspase-3 plays an essential role in the pathological process of neurodegenerative diseases. In the process, caspase-3 not only performs as apoptosis effector, but also interacts directly with the pathogenic protein molecules of these diseases, such as Alzheimer's disease, Parkinson's disease, Huntington disease and Spinocerebellar ataxia, particpating in their pathogenic mechanism. Therefore, caspase-3 is a new target for neurodegenerative diseases treatment, the search for caspase-3 inhibitors with high effectivity and selectivity will supply a novel way to cure neurodegenerative diseases.
WOS关键词TRAUMATIC BRAIN INJURY ; APOPTOSIS ; CLEAVAGE ; CELLS ; TAU
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种中文
CSCD记录号CSCD:1301405
WOS记录号WOS:000182764700003
出版者SCIENCE CHINA PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/274250]  
专题中国科学院上海药物研究所
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
2.E China Normal Univ, Acad Life Sci, Shanghai 200062, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, YH,Li, J,Zhou, ZL. Caspase-3: a new target for neurodegenerative diseases treatment[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2003,30(2):175-179.
APA Zhang, YH,Li, J,&Zhou, ZL.(2003).Caspase-3: a new target for neurodegenerative diseases treatment.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,30(2),175-179.
MLA Zhang, YH,et al."Caspase-3: a new target for neurodegenerative diseases treatment".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 30.2(2003):175-179.

入库方式： OAI收割

来源：上海药物研究所

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