(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro
文献类型：期刊论文
| 作者 | Guo, H; Yu, Y; Xing, L; Jin, GZ ; Zhou, JW
|
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2002-11-15 |
| 卷号 | 13期号:16页码:2085-2089 |
| 关键词 | differentiation neural precursor cells rat stepholidine tyrosine hydroxylase tissue culture |
| ISSN号 | 0959-4965 |
| DOI | 10.1097/00001756-200211150-00019 |
| 文献子类 | Article |
| 英文摘要 | The present study investigated the influence of (-)-stepholidine, an effective dopamine D-1 receptor agonist and D-2 receptor antagonist, on the development of neural precursor cells. Incubation of striatal neural precursor cells with stepholidine resulted in significant increase in the number of proliferating precursor cell spheres when in the presence of fibroblast growth factor-2. This action can be blocked by application of haloperidol. Treatment with stepholidine also increased the number of microtubule-associated protein-2-immunoreactive cells in the cultures and promoted marked increases in tyrosine hydroxylase expression. These findings suggest that stepholidine is involved in the regulation of proliferation of precursor cells. The effect appears to be mediated by dopamine receptors. Stepholidine also promotes the differentiation of precursor cells, however, this action may be independent of its effect on dopaminergic receptors. |
| WOS关键词 | TYROSINE-HYDROXYLASE EXPRESSION ; CILIARY NEUROTROPHIC FACTOR ; FIBROBLAST GROWTH FACTOR-2 ; NEURAL STEM-CELL ; DOPAMINERGIC PHENOTYPE ; IN-VITRO ; GENERATION ; FOREBRAIN ; INDUCTION ; RECEPTOR |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000179821600019 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274310]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhou, JW |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Proteom, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, H,Yu, Y,Xing, L,et al. (-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro[J]. NEUROREPORT,2002,13(16):2085-2089. |
| APA | Guo, H,Yu, Y,Xing, L,Jin, GZ,&Zhou, JW.(2002).(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro.NEUROREPORT,13(16),2085-2089. |
| MLA | Guo, H,et al."(-)-Stepholidine promotes proliferation and neuronal differentiation of rat embryonic striatal precursor cells in vitro".NEUROREPORT 13.16(2002):2085-2089. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。