Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages
文献类型：期刊论文
| 作者 | Feng, YH; Zou, JP; Li, XY |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2002-11 |
| 卷号 | 23期号:11页码:1002-1006 |
| ISSN号 | 1671-4083 |
| 关键词 | resveratrol ethanol macrophages nitric oxide tumor necrosis factor interleukin-1 interleukin-6 lipopolysaccharides |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the interaction of resveratrol and ethanol on the production of pro-inflammatory factors from activated murine peritoneal macrophages (MPM). METHODS: NO production was measured with Griess assay; IL-1 production was measured through thymocyte co-stimulating assay; IL-6 and TNF-alpha were detected by ELISA method. RESULTS: Resveratrol (6.25, 12.5, 25 mumol/L) and ethanol (0.2%, 0.8%) synergistically inhibited the 24 h production of NO from lipopolysaccharide (LPS, 1 mg/L) and IFN-gamma (5 kU/L) stimulated MPM; resveratrol at higher dose (25 mumol/L) also inhibited IL-6 production. Ethanol additively strengthened this effect. Ethanol had no significant influence on 24 h MPM IL-1 production, but it promoted the ability of resveratrol on enhancing the IL-1 release from activated MPM. Low doses of ethanol inhibited 24 h production of TNF-alpha, however, both dose of ethanol enhanced the promoting effect of resveratrol on TNF-alpha production. CONCLUSION: Resveratrol and ethanol can interact to influence the production of macrophage function molecules, which is noteworthy in evaluating the health-care effect of wine consumption. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; IN-VITRO ; MESSENGER-RNA ; ALCOHOL ; WINE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| WOS记录号 | WOS:000179049300008 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274311]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zou, JP |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Lab Immunopharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, YH,Zou, JP,Li, XY. Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages[J]. ACTA PHARMACOLOGICA SINICA,2002,23(11):1002-1006. |
| APA | Feng, YH,Zou, JP,&Li, XY.(2002).Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages.ACTA PHARMACOLOGICA SINICA,23(11),1002-1006. |
| MLA | Feng, YH,et al."Effects of resveratrol and ethanol on production of pro-inflammatory factors from endotoxin activated murine macrophages".ACTA PHARMACOLOGICA SINICA 23.11(2002):1002-1006. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。