Low dose of resveratrol enhanced immune response of mice
文献类型：期刊论文
| 作者 | Feng, YH; Zhou, WL; Wu, QL; Li, XY; Zhao, WM ; Zou, JP
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2002-10 |
| 卷号 | 23期号:10页码:893-897 |
| 关键词 | resveratrol T-lymphocytes interleukin-12 interleukin-10 interferon type II delayed hypersensitivity ethanol |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the immune modulating effect of low dose of resveratrol. METHODS: Concanavalin A (ConA) and Staphylococcus aureus Cowan (Sac) were used to induce the activation of T lymphocyte and antigen presenting cell and cytokine production. [H-3]-Thymidine incorporation was used to evaluate the proliferation of lymphocyte. Cytokine production was detected by ELISA method. Dinitrofluorobenzene (DNFB) was used to induce mice delayed type hypersensitivity (DTH, delayed hypersensitivity) response and ear swelling was used as an evaluating indicator. Changes of lymphocyte subtypes were detected by flow cytometry. RESULTS: Resveratrol (0.75-6 mumol/L) concentration-dependently promoted lymphocyte proliferation and IL-2 production induced by ConA. Sac induced IL-12 and IFN-gamma (interferon type II) production were also concentration-dependently enhanced by resveratrol, while IL-10 production was inhibited. Resveratrol (4 mg/kg, ig) promoted DTH response of mouse, which was suppressed by ethanol (16 %, w/v) consumption. Resveratrol treatment had no significant influence on lymphocyte subtypes in mice, however it could reverse the suppressive effect of ethanol both on macrophage percentage and on macrophage MHC-II molecule expression. CONCLUSION: Low dose resveratrol enhanced cell-mediate immune response. Promoting Th1 cytokine production and influencing on macrophage function might be its mechanisms. |
| WOS关键词 | PROLIFERATION ; SUPPRESSION ; MACROPHAGES |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:510149 |
| WOS记录号 | WOS:000178631100006 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274320]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zou, JP |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Lab Immunopharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, YH,Zhou, WL,Wu, QL,et al. Low dose of resveratrol enhanced immune response of mice[J]. ACTA PHARMACOLOGICA SINICA,2002,23(10):893-897. |
| APA | Feng, YH,Zhou, WL,Wu, QL,Li, XY,Zhao, WM,&Zou, JP.(2002).Low dose of resveratrol enhanced immune response of mice.ACTA PHARMACOLOGICA SINICA,23(10),893-897. |
| MLA | Feng, YH,et al."Low dose of resveratrol enhanced immune response of mice".ACTA PHARMACOLOGICA SINICA 23.10(2002):893-897. |
入库方式： OAI收割
来源：上海药物研究所
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