Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity
文献类型：期刊论文
| 作者 | Zhao, HW; Li, XY |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2002-10 |
| 卷号 | 2期号:11页码:1551-1556 |
| 关键词 | ginkgolides huperzine a nitric oxide cell growth apoptosis SK-N-SH cells |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/S1567-5769(02)00093-0 |
| 文献子类 | Article |
| 英文摘要 | Nitric oxide (NO) is believed to play important roles in neuronal degeneration. In this study, the effects of NO on cell growth and apoptosis have been examined in human neuroblastoma cell line SK-N-SH. Sodium nitroprusside (SNP), a NO donor, was found to significantly inhibit cell growth and to induce apoptosis. The inhibitory and apoptotic activities of SNP followed a dose- and time-dependent manner. Ginkgolide A, B (GA, 13), and huperzine A (Hup A), the three compounds isolated from Chinese herbs, blocked the inhibition of cell growth and apoptosis induced by SNP. The results suggest that inhibition of NO-induced neurotoxicity may be one mechanism of the above three therapeutic agents in neurodegenerative diseases. (C) 2002 Elsevier Science B.V All rights reserved. |
| WOS关键词 | BILOBA EXTRACT EGB-761 ; CELL-DEATH ; IN-VITRO ; MECHANISMS ; CYTOKINES ; APOPTOSIS ; GROWTH ; INVOLVEMENT ; TOXICITY ; RESCUES |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000179095700005 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274326]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, HW |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, HW,Li, XY. Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2002,2(11):1551-1556. |
| APA | Zhao, HW,&Li, XY.(2002).Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity.INTERNATIONAL IMMUNOPHARMACOLOGY,2(11),1551-1556. |
| MLA | Zhao, HW,et al."Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity".INTERNATIONAL IMMUNOPHARMACOLOGY 2.11(2002):1551-1556. |
入库方式： OAI收割
来源：上海药物研究所
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