Structure-based 3-D-QSAR analysis of marine indole alkaloids
文献类型：期刊论文
| 作者 | Jiang, B; Xiong, WN; Yang, CG ; Jiang, HL; Cheng, F; Chen, KX
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 出版日期 | 2002-08 |
| 卷号 | 10期号:8页码:2775-2778 |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/S0968-0896(02)00057-3 |
| 文献子类 | Article |
| 英文摘要 | A 3-D-QSAR study has been performed on these indole alkaloid derivatives to correlate their chemical structures with their observed antitumor activity against IGROV1. Due to the absence of information on their active mechanism, comparative molecular field analysis (CoMFA) has been applied. A model able to well correlate the antitumor activity with the chemical structures of mono and bis(indole) alkaloids 1-18 has been developed which is potentially helpful in the design of novel and more potent antitumor agents. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| WOS关键词 | CYTOTOXICITY EVALUATION ; TOPOISOMERASE-I ; INDOLYLPYRIMIDINES ; TRANSCRIPTION ; ANALOGS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000176294500036 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274340]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jiang, B |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, B,Xiong, WN,Yang, CG,et al. Structure-based 3-D-QSAR analysis of marine indole alkaloids[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2002,10(8):2775-2778. |
| APA | Jiang, B,Xiong, WN,Yang, CG,Jiang, HL,Cheng, F,&Chen, KX.(2002).Structure-based 3-D-QSAR analysis of marine indole alkaloids.BIOORGANIC & MEDICINAL CHEMISTRY,10(8),2775-2778. |
| MLA | Jiang, B,et al."Structure-based 3-D-QSAR analysis of marine indole alkaloids".BIOORGANIC & MEDICINAL CHEMISTRY 10.8(2002):2775-2778. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。