Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia
文献类型：期刊论文
| 作者 | Zhao, Y; Hao, XJ; Lu, W; Cai, JC; Yu, H; Sevenet, T; Gueritte, F |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2002-06 |
| 卷号 | 65期号:6页码:902-908 |
| ISSN号 | 0163-3864 |
| DOI | 10.1021/np0200257 |
| 文献子类 | Article |
| 英文摘要 | Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines. |
| WOS研究方向 | Plant Sciences ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000176688300018 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274355]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhao, Y |
| 作者单位 | 1.Inmore Lab Biotechnol, Kunming 650011, Peoples R China 2.CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France 3.Zhejiang Univ, Coll Pharmaceut Sci, Dept Tradit Chinese Med & Nat Drug Res, Hangzhou 310031, Peoples R China 4.Chinese Acad Sci, Kunming Inst Bot, Lab Phytochem, Kunming 650204, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Y,Hao, XJ,Lu, W,et al. Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia[J]. JOURNAL OF NATURAL PRODUCTS,2002,65(6):902-908. |
| APA | Zhao, Y.,Hao, XJ.,Lu, W.,Cai, JC.,Yu, H.,...&Gueritte, F.(2002).Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.JOURNAL OF NATURAL PRODUCTS,65(6),902-908. |
| MLA | Zhao, Y,et al."Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia".JOURNAL OF NATURAL PRODUCTS 65.6(2002):902-908. |
入库方式： OAI收割
来源：上海药物研究所
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