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Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage functions in mice
文献类型：期刊论文
| 作者 | Wang, YP ; Li, XY; Song, CQ; Hu, ZB
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2002-03 |
| 卷号 | 23期号:3页码:263-266 |
| 关键词 | Astragalus membranaceus saponins T-lymphocytes B-lymphocytes antibody formation peritoneal macrophages interleukin-1 tumor necrosis factor |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To investigate the effect of astragaloside IV (ASI) on T, B lymphocyte proliferation, antibody production, and cytokines produced by murine peritoneal macrophages. METHODS: MTT assay was used to determine T, B lymphocyte proliferation and quantitative hemolysin spectrophotometry (QHS) assay was applied to test antibody production; IL-1 production was measured by thymocyte proliferation assay; TNF-alpha production was determined by the cytotoxicity assay against L929 cells. RESULTS: 1) In vivo, ASI 50 - 200 mg/kg ig for 7 d increased T lymphocyte proliferation and antibody production, and ASI 50 - 100 mg/kg ig for 7 d increased B lymphocyte proliferation but ASI 200 mg/kg had no effect on B lymphocyte proliferation; 2) In vitro, ASI increased T, B lymphocyte proliferation only at 100 nmol/L; 3) ASI increased IL-1 activity at I nmol/L in vitro, but decreased it at 100 and 1000 nmol/L; 4) ASI inhibited TNF-alpha activity with or without LPS-stimulation in vitro. CONCLUSION: ASI increased T, B lymphocyte proliferation and antibody production in vivo and in vitro; but inhibited productions of IL-1 and TNF-alpha from peritoneal macrophages in vitro. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; IN-VITRO ; INTERLEUKIN-1 ; RADIX |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:1366792 |
| WOS记录号 | WOS:000174223200013 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274376]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, XY |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, YP,Li, XY,Song, CQ,et al. Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage functions in mice[J]. ACTA PHARMACOLOGICA SINICA,2002,23(3):263-266. |
| APA | Wang, YP,Li, XY,Song, CQ,&Hu, ZB.(2002).Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage functions in mice.ACTA PHARMACOLOGICA SINICA,23(3),263-266. |
| MLA | Wang, YP,et al."Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage functions in mice".ACTA PHARMACOLOGICA SINICA 23.3(2002):263-266. |
入库方式： OAI收割
来源：上海药物研究所
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