Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction
文献类型：期刊论文
| 作者 | Clozel, M; Qiu, CB; Qiu, CS; Hess, P; Clozel, JP |
| 刊名 | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
 |
| 出版日期 | 2002-01-02 |
| 卷号 | 39期号:1页码:142-147 |
| ISSN号 | 0735-1097 |
| DOI | 10.1016/S0735-1097(01)01692-8 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVES We investigated the effects of short-term tezosentan treatment on cardiac function, pulmonary edema and long-term evolution of heart failure (HF) in a rat model of myocardial infarction (MI). BACKGROUND Endothelin (ET) may play a major role in the progression from MI to HF. Tezosentan is a new dual ETA/ETB receptor antagonist. METHODS Rats were subjected to coronary artery ligation and were treated with either vehicle or tezosentan (10 mg/kg IV bolus) at 1 h and 24 h after MI. Cardiac hemodynamics and lung weight were measured at 48 h after MI. Survival was assessed over a five-month period. RESULTS At 48 h after ligation, vehicle-treated rats developed HF, as evidenced by a marked increase in left ventricular end-diastolic pressure (LVEDP), reduction in dP/dt(max) and mean arterial pressure (MAP), and development of pulmonary edema. Tezosentan treatment attenuated the increase in LVEDP and in lung weight and slightly reduced MAP without affecting dP/dt(max). Infarct size was not modified by tezosentan. Despite the fact that treatment with tezosentan was stopped after 24 h, the initial tezosentan administration significantly reduced cardiac hypertrophy (22%) and decreased mortality by 51% at five months (50% survival vs. 19% survival in vehicle-treated rats, p < 0.001). CONCLUSIONS Tezosentan administered during the first day after MI in rats, in addition to improving acutely hemodynamic conditions, markedly increases long-term survival. This increase is associated with a decrease of pulmonary edema and prevention of cardiac hypertrophy. Tezosentan could be a safe and useful therapeutic agent in the prevention and treatment of ischemic HF. (J Am Coll Cardiol 2002;39:142-7) (C) 2002 by the American College of Cardiology. |
| WOS关键词 | CHRONIC HEART-FAILURE ; ENDOGENOUS ENDOTHELIN ; ANTAGONIST BOSENTAN ; HYPERTENSIVE RATS ; BLOOD-PRESSURE ; CARDIAC-FUNCTION ; ALBUMIN ESCAPE ; CONSCIOUS RATS ; PLASMA-VOLUME ; LUNG INJURY |
| WOS研究方向 | Cardiovascular System & Cardiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000173007500022 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274404]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Clozel, JP |
| 作者单位 | 1.Shanghai Inst Mat Med, Dept Pharmacol, Shanghai, Peoples R China 2.Actelion Pharmaceut Ltd, Innovat Ctr, CH-4123 Allschwil, Switzerland |
| 推荐引用方式 GB/T 7714 | Clozel, M,Qiu, CB,Qiu, CS,et al. Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2002,39(1):142-147. |
| APA | Clozel, M,Qiu, CB,Qiu, CS,Hess, P,&Clozel, JP.(2002).Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,39(1),142-147. |
| MLA | Clozel, M,et al."Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 39.1(2002):142-147. |
入库方式： OAI收割
来源：上海药物研究所
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