Effects of salviainolic acid A (SA-A) on liver injury: SA-A action on hepatic peroxidation
文献类型：期刊论文
| 作者 | Liu, P; Hu, YY; Liu, CH; Liu, C; Zhu, DY |
| 刊名 | LIVER
 |
| 出版日期 | 2001-12 |
| 卷号 | 21期号:6页码:384-390 |
| 关键词 | ALT AST carbon tetrachloride catalase (CAT) glutathione (GSH) glutathione peroxidase (GSH-PX) hepatocyte lactase dehydrogenase (LDH) lipid peroxidation liver fibrosis liver injury malondiadehyde (MDA) salviainolic acid A superoxide dismutase (SOD) |
| ISSN号 | 0106-9543 |
| DOI | 10.1034/j.1600-0676.2001.210604.x |
| 文献子类 | Article |
| 英文摘要 | Background/Aims: This study aimed to investigate the actions of salviainolic acid A (SA-A). an antiperoxidative component of Salvia miltiorrhiza (Sm). on rat liver injury and fibrosis. Methods: Acute and chronic rat liver injury models were established using carbon tetrachloride (CCl4). After 48 h (acute) or during 6 weeks of CCl4 injection, rats were further divided and treated with biphenyl dimethyl-dicarboxylate (BDD) or colchicine. as a control antifibrotic treatment, with Sm, a herbal compound. or SA-A. a water-soluble extract of Sin. Liver function was investigated by assessing alanine transaminase (ALT) and aspartate transaminase (AST) activities. histological analysis, hydroxyproline (Hyp) and malondiadehyde (MDA) content. In vitro, isolated cultured hepatocytes were injured with CCl4 gas for 24 h, followed by treatment with either vitamin E or various concentrations of SA-A. The extent of hepatocyte injury was monitored by analyzing various lipid peroxidative parameters such as superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), lactase dehydrogenase (LDH), and glutathione peroxidase (GSH-PX) levels in hepatocyte supernatants. Results: SA-A significantly decreased abnormal serum ALT activity both in acutely and chronically injured rat livers, decreased abnormal serum AST activity. Hyp and MDA content and attenuated hepatic collagen deposition. After CCl4 incubation and injury, the activities of AST ALT CAT. GSH-PX and LDH and MDA content in hepatocyte supernatants increased significantly, but GSH levels decreased significantly. SA-A markedly improved these pathological changes in a dose-dependent manner. 10(-4) mol/l SA-A had stronger inhibitory action than vitamin E. Conclusions: Our studies suggest that SA-A has antiperoxidative effects on injured hepatocytes in liver injury and Fibrosis induced by CCl4. |
| WOS关键词 | LIPID-PEROXIDATION ; CELLS ; RATS |
| WOS研究方向 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000172466000004 |
| 出版者 | MUNKSGAARD INT PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274423]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, P |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Inst Liver Dis, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Meteria Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, P,Hu, YY,Liu, CH,et al. Effects of salviainolic acid A (SA-A) on liver injury: SA-A action on hepatic peroxidation[J]. LIVER,2001,21(6):384-390. |
| APA | Liu, P,Hu, YY,Liu, CH,Liu, C,&Zhu, DY.(2001).Effects of salviainolic acid A (SA-A) on liver injury: SA-A action on hepatic peroxidation.LIVER,21(6),384-390. |
| MLA | Liu, P,et al."Effects of salviainolic acid A (SA-A) on liver injury: SA-A action on hepatic peroxidation".LIVER 21.6(2001):384-390. |
入库方式： OAI收割
来源：上海药物研究所
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