IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4(+) and CD8(+) T cells
文献类型：期刊论文
| 作者 | Yang, YF; Tomura, M; Iwasaki, M; Ono, S; Zou, JP; Uno, K; Shearer, GM; Fujiwara, H; Hamaoka, T |
| 刊名 | JOURNAL OF CLINICAL IMMUNOLOGY
 |
| 出版日期 | 2001-11 |
| 卷号 | 21期号:6页码:402-409 |
| 关键词 | IFN-alpha IL-12 chemokine receptor CCR5 T cell |
| ISSN号 | 0271-9142 |
| DOI | 10.1023/A:1013173610032 |
| 文献子类 | Article |
| 英文摘要 | Interleukin-12 (IL-12) as well as IL-2 was recently shown to up-regulate CCR5 expression on T-cell receptor (TCR)triggered human T cells. Because of the functional similarity between interferon-alpha (IFN-alpha) and IL-12. the present study investigated whether IFN-alpha also up-regulates T cell CCR5 expression. CCR5 was marginally detected on T cells from unstimulated human peripheral blood leukocytes (PBLs) and only slightly induced on PBL T cells following stimulation with anti-CD3 plus anti-CD28 monoclonal antibodies (mAbs). When anti-CD3/anti-CD28-triggered PBLs were exposed to IFN-alpha. T cells expressed high levels of CCR5. The levels of CCR5 expression were comparable to those induced by IL-12. However, when purified T cells instead of unfractionated PBL were stimulated with anti-CD3/CD28 and then exposed to IL-12 or IFN-alpha. CCR5 expression was induced by IL-12 but not by IFN-alpha. IFN-alpha was found to act on anti-CD3/anti-CD28-stimulated PBL to promote their IL-12 production. Moreover, addition of anti-IL-12 mAb to IFN-alpha-stimulated cultures of anti-CD3/CD28-pretreated PBL resulted in considerable inhibition of CCR5 expression. Together, these results indicate that IFN-alpha as well as IL-12 up-regulates CCR5 expression on TCR-triggered T cells and that IFN-alpha functions not by acting directly on T cells but via enhancing IL-12 production by PBL. |
| WOS关键词 | INTERFERON-GAMMA PRODUCTION ; NATURAL-KILLER ; CHEMOKINE RECEPTORS ; STIMULATORY FACTOR ; CHEMOTACTIC RESPONSIVENESS ; CYTOKINE RESPONSES ; IL-12 PRODUCTION ; INTERLEUKIN-12 ; LYMPHOCYTES ; STAT4 |
| WOS研究方向 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000173317900004 |
| 出版者 | KLUWER ACADEMIC/PLENUM PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274439]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fujiwara, H |
| 作者单位 | 1.NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA 2.Osaka Univ, Grad Sch Med, Dept Oncol C6, Biomed Res Ctr, Suita, Osaka 5650871, Japan 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 4.Louis Pasteur Ctr Med Res, Kyoto 606, Japan |
| 推荐引用方式 GB/T 7714 | Yang, YF,Tomura, M,Iwasaki, M,et al. IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4(+) and CD8(+) T cells[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2001,21(6):402-409. |
| APA | Yang, YF.,Tomura, M.,Iwasaki, M.,Ono, S.,Zou, JP.,...&Hamaoka, T.(2001).IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4(+) and CD8(+) T cells.JOURNAL OF CLINICAL IMMUNOLOGY,21(6),402-409. |
| MLA | Yang, YF,et al."IFN-alpha acts on T-cell receptor-triggered human peripheral leukocytes to up-regulate CCR5 expression on CD4(+) and CD8(+) T cells".JOURNAL OF CLINICAL IMMUNOLOGY 21.6(2001):402-409. |
入库方式： OAI收割
来源：上海药物研究所
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