PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation, and in vitro characterization
文献类型：期刊论文
| 作者 | Li, YP ; Zhou, ZH; Pei, YY; Zhang, XY; Gu, ZH; Yuan, WF
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2001-07 |
| 卷号 | 22期号:7页码:645-650 |
| 关键词 | polyethylene glycols poly (alkyl cyanoacrylate) nanoparticles salvicine |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To synthesized poly( methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate)( PEGylated PHDCA) with polyethylene glycol (PEG, M-r = 5000), prepare PEGylated PHDCA and poly ( n-hexadecyl cyanoacrylate) (PHDCA) nanoparticles loading salvicine and determine their in vitro characterizations. METHODS: The structure of PEGylated PHDCA was determined with H-1-NMR, C-13-NMR and Fourier transform infrared spectrum (FTIR). Its molecular weight was determined by gel permeation chromatography (GPC). Nanoparticles were prepared by emulsion/solvent evaporation method. RESULTS: 1H-NMR, 13C-NMR, and FTIR were consistent with structure of PEGylated PHDCA, whose average molecular weight is 6680. Entrapment efficiency could be determined by high pressure liquid chromatography (HPLC) method without endogenous interference at the retention time of salvicine. The entrapment efficiency was 92.6 % for PEGylated PHDCA nanoparticles and 98.9 % for PHDCA nanoparticles. The nanoparticles size was about 250nm. The values of the zeta potential were obviously influenced by the composition of the copolymer. Compared with PHDCA nanoparticles (-23.1 mV), PEGylated PHDCA nanoparticles showed a low surface potential (- 9.6 mV). Salvicine release from nanoparticles showed an initial burst effect, then a plateau for an extended period, and finally sustained release phase. CONCLUSION: These results showed that the PEGylated PHDCA nanoparticles could be an effective carrier for salvicine delivery in the respect of anti-tumor potency. |
| WOS关键词 | AMPHIPHILIC COPOLYMER ; NANOSPHERES ; GLYCOL) |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000169950000012 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274473]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, YP |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Materia Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, YP,Zhou, ZH,Pei, YY,et al. PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation, and in vitro characterization[J]. ACTA PHARMACOLOGICA SINICA,2001,22(7):645-650. |
| APA | Li, YP,Zhou, ZH,Pei, YY,Zhang, XY,Gu, ZH,&Yuan, WF.(2001).PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation, and in vitro characterization.ACTA PHARMACOLOGICA SINICA,22(7),645-650. |
| MLA | Li, YP,et al."PEGylated polycyanoacrylate nanoparticles as salvicine carriers: synthesis, preparation, and in vitro characterization".ACTA PHARMACOLOGICA SINICA 22.7(2001):645-650. |
入库方式： OAI收割
来源：上海药物研究所
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