Progress in the design of matrix metalloproteinase inhibitors
文献类型：期刊论文
| 作者 | Cheng, F; Liu, H ; Luo, XM; Jiang, HL; Shen, JK; Chen, KX; Ji, RY
|
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2001-07 |
| 卷号 | 13期号:4页码:283-293 |
| 关键词 | matrix metalloproteinase inhibitor substrate-based design structure-based design combinatorial chemistry SAR-by-NMR |
| ISSN号 | 1005-281X |
| 文献子类 | Article |
| 英文摘要 | Matrix metalloproteinase (MMP) is a family of zinc proteinases. The excess of these proteinases leads to the accelerated extracellular matrix degradation associated with diseases such as arthritis, cancer and multiple sclerosis. The research of MMP inhibitors is an active field of drug design. In recent years, three methods of molecular design have been developed, including substrate-based design, structure-based design and combinatorial chemistry technology. The principle of these methods and their applications in MMP inhibitor design are summarized in this review. |
| WOS关键词 | HUMAN FIBROBLAST COLLAGENASE ; DRUG DESIGN ; COMBINATORIAL TECHNOLOGIES ; CYSTEINE SWITCH ; LIBRARY ; DISCOVERY ; IDENTIFICATION ; CHEMISTRY ; MEMBRANE ; CLONING |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:642252 |
| WOS记录号 | WOS:000172152400007 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274478]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Cheng, F |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cheng, F,Liu, H,Luo, XM,et al. Progress in the design of matrix metalloproteinase inhibitors[J]. PROGRESS IN CHEMISTRY,2001,13(4):283-293. |
| APA | Cheng, F.,Liu, H.,Luo, XM.,Jiang, HL.,Shen, JK.,...&Ji, RY.(2001).Progress in the design of matrix metalloproteinase inhibitors.PROGRESS IN CHEMISTRY,13(4),283-293. |
| MLA | Cheng, F,et al."Progress in the design of matrix metalloproteinase inhibitors".PROGRESS IN CHEMISTRY 13.4(2001):283-293. |
入库方式： OAI收割
来源：上海药物研究所
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