A kinetic study on the interaction of deprotonated purine radical cations with amino acids and model peptides
文献类型：期刊论文
| 作者 | Pan, JX; Lin, WH; Wang, WF; Han, ZH; Lu, CY; Yao, S ; Lin, NY; Zhu, DY
|
| 刊名 | BIOPHYSICAL CHEMISTRY
 |
| 出版日期 | 2001-02-15 |
| 卷号 | 89期号:2-3页码:193-199 |
| 关键词 | oxidative damage purine radical cation electron transfer pulse radiolysis |
| ISSN号 | 0301-4622 |
| DOI | 10.1016/S0301-4622(00)00235-0 |
| 文献子类 | Article |
| 英文摘要 | By use of pulse radiolysis techniques, the radical cations of purine nucleotides have been successfully produced by the SO4.- ion oxidation. Time-resolved spectroscopic evidence is provided that the one-electron-oxidized radicals of dAMP and dGMP can be efficiently repaired by aromatic amino acids (including tyrosine and tryptophan) via electron transfer reaction. As a model peptide, Arg-Tyr-AcOH was also investigated with regard to its interaction with deprotonated purine radical cations. The rate constants of the electron transfer reactions were determined to be (1 similar to 5) X 10(8) dm(3) mol(-1) s(-1). These results suggest that the aromatic amino acids in DNA-associated proteins may play some role in electron transfer reactions through DNA. (C) 2001 Elsevier Science B.V. All rights reserved. |
| WOS关键词 | ELECTRON-TRANSFER ; AQUEOUS-SOLUTION ; LASER PHOTOLYSIS ; OXIDATIVE DAMAGE ; DNA-DAMAGE ; GUANOSINE ; MIGRATION ; CLEAVAGE ; ANTHRAQUINONES ; NUCLEOTIDES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000167089500008 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274522]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yao, S |
| 作者单位 | 1.Acad Sinica, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Acad Sinica, Shanghai Inst Nucl Res, Lab Radiat Chem, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, JX,Lin, WH,Wang, WF,et al. A kinetic study on the interaction of deprotonated purine radical cations with amino acids and model peptides[J]. BIOPHYSICAL CHEMISTRY,2001,89(2-3):193-199. |
| APA | Pan, JX.,Lin, WH.,Wang, WF.,Han, ZH.,Lu, CY.,...&Zhu, DY.(2001).A kinetic study on the interaction of deprotonated purine radical cations with amino acids and model peptides.BIOPHYSICAL CHEMISTRY,89(2-3),193-199. |
| MLA | Pan, JX,et al."A kinetic study on the interaction of deprotonated purine radical cations with amino acids and model peptides".BIOPHYSICAL CHEMISTRY 89.2-3(2001):193-199. |
入库方式： OAI收割
来源：上海药物研究所
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