Magnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidation
文献类型：期刊论文
| 作者 | Karmin, O; Lynn, EG; Vazhappilly, R; Au-Yeung, KKW; Zhu, DY; Siow, YL |
| 刊名 | LIFE SCIENCES
 |
| 出版日期 | 2001-01-12 |
| 卷号 | 68期号:8页码:903-912 |
| 关键词 | low density lipoproteins (LDL) oxidation magnesium tanshinoate B (MTB) macrophages foam cells |
| ISSN号 | 0024-3205 |
| DOI | 10.1016/S0024-3205(00)00989-9 |
| 文献子类 | Article |
| 英文摘要 | Danshen, a Chinese herbal medicine has been widely used for the treatment of cardiovascular diseases. Magnesium tanshinoate B (MTB) is an active compound purified from Danshen. The objective of this study was to investigate the effect of MTB on the susceptibility of low density lipoproteins (LDL) to oxidative modification as well as on the accumulation of lipids in THP-1 derived macrophages, Aliquots of LDL were incubated with copper sulfate in the absence or presence of MTB. The degrees of oxidative modification of LDL were assessed by examining the relative gel electrophoretic mobility, by measuring the amount of thiobarbituric acid reactive substances (TBARS), and by continuous monitoring of the formation of conjugated dienes upon the increase in absorbency at 234 nm. MTB at concentrations of 1-10 muM significantly inhibited oxidative modification of LDL. Such inhibitory effect resulted in a decrease in the uptake of LDL by THP-1 derived macrophages. Taken together, these results clearly demonstrate that MTB inhibits oxidative modification of LDL and hence prevents the uptake of LDL by cultured macrophages. Such effect may be therapeutically relevant in protecting cells from lipid peroxidation in vascular disorders. (C) 2001 Elsevier Science Inc. All rights reserved. |
| WOS关键词 | CHOLESTEROL DEPOSITION ; SALVIA-MILTIORRHIZA ; LIPID-PEROXIDATION ; CORONARY-ARTERY ; IIA SULFONATE ; FATTY STREAK ; IN-VITRO ; ATHEROSCLEROSIS ; CELLS ; LESIONS |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000166536500006 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274528]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Siow, YL |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Univ Hong Kong, Fac Med, Sch Tradit Chinese Med, Hong Kong, Hong Kong, Peoples R China 3.Univ Hong Kong, Fac Med, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Karmin, O,Lynn, EG,Vazhappilly, R,et al. Magnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidation[J]. LIFE SCIENCES,2001,68(8):903-912. |
| APA | Karmin, O,Lynn, EG,Vazhappilly, R,Au-Yeung, KKW,Zhu, DY,&Siow, YL.(2001).Magnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidation.LIFE SCIENCES,68(8),903-912. |
| MLA | Karmin, O,et al."Magnesium tanshinoate B (MTB) inhibits low density lipoprotein oxidation".LIFE SCIENCES 68.8(2001):903-912. |
入库方式： OAI收割
来源：上海药物研究所
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