Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick
文献类型：期刊论文
| 作者 | Gao, Y; Tang, XC ; Guan, LC; Kuang, PZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-12 |
| 卷号 | 21期号:12页码:1169-1173 |
| 关键词 | cholinesterases huperzine A scopolamine muscimol GABA avoidance learning memory chickens |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effects of huperzine A on disruption of spatial memory induced by scopolamine (a muscarinic antagonist) and muscimol (a GABA(A) agonist) in passive avoidance task. METHODS: One-trial passive avoidance task was used to investigate the effects of huperzine A. The avoidance rate was used to evaluate memory retention. RESULTS: Both scopolamine (100 ng)and muscimol (50 ng), injected intracranially 5 min before training, resulted in a decreased avoidance rate. Huperzine A (25 ng), injected intracranially 15 min before training, reversed memory deficits induced by scopolamine and muscimol at 30 min after training, and this reversal persisted at least 1 h. The improving effects of huperzine A exhibited a bell-shaped dose-response curve. CONCLUSION: Huperzine A improved the process of memory formation not only by acting as a highly potent and selective inhibitor of AChE, but also by antagonizing effects mediated through the GABA(A) receptor. |
| WOS关键词 | HYPERSTRIATUM-VENTRALE ; WORKING-MEMORY ; INTERMEDIATE ; IMPAIRMENT ; TACRINE ; E2020 ; MAZE ; GABA |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000165828500019 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274551]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tang, XC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Y,Tang, XC,Guan, LC,et al. Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick[J]. ACTA PHARMACOLOGICA SINICA,2000,21(12):1169-1173. |
| APA | Gao, Y,Tang, XC,Guan, LC,&Kuang, PZ.(2000).Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick.ACTA PHARMACOLOGICA SINICA,21(12),1169-1173. |
| MLA | Gao, Y,et al."Huperzine A reverses scopolamine- and muscimol-induced memory deficits in chick".ACTA PHARMACOLOGICA SINICA 21.12(2000):1169-1173. |
入库方式： OAI收割
来源：上海药物研究所
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