Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients
文献类型：期刊论文
| 作者 | Lu, DY; Chen, XL; Cao, JY; Li, Z; Xue, HW; Luo, LJ; Xu, B
|
| 刊名 | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
 |
| 出版日期 | 2000-11 |
| 卷号 | 28期号:6页码:313-317 |
| 关键词 | fibrinogen blood fibrinogen concentration cancer chemotherapy tumour pathogenesis |
| ISSN号 | 0300-0605 |
| DOI | 10.1177/147323000002800608 |
| 文献子类 | Article |
| 英文摘要 | Blood fibrinogen concentrations and glutamic-pyruvic transaminase activities of 66 adult cancer inpatients (aged 22 - 70 years) were determined both before and after one or two chemotherapy regimens. The percentage of hepatoma patients with abnormal blood fibrinogen levels (< 1.5 or > 6.0 g/l) was higher (64.3% of 14 patients) than that in other cancer categories (19.2% of 52 patients). The mean blood fibrinogen concentrations of male (3.5 g/l) and female (4.5 g/l) cancer patients were higher than those previously reported for healthy humans (2.8 and 2.9 g/l, respectively). After chemotherapy, blood fibrinogen concentrations decreased in patients whose primary tumours were surgically removed (from 4.8 to 3.2 g/l) but increased (from 3.0 to 4.8 gn) in those who did not undergo surgery. Glutamic-pyruvic transaminase activities did not appear to be related to blood fibrinogen levels. We conclude that the increase in mean blood fibrinogen levels of cancer patients is probably related to tumour growth. Different mechanisms may operate in patients with hepatoma. |
| WOS关键词 | TUMOR ; COAGULATION ; PROTECTION ; CARCINOMA ; PROSTATE ; CELLS ; LUNG |
| WOS研究方向 | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000166089300008 |
| 出版者 | CAMBRIDGE MED PUBL |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274563]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Lu, DY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 200436, Peoples R China 3.Cent Hosp Jing An Dist, Shanghai 200040, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, DY,Chen, XL,Cao, JY,et al. Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2000,28(6):313-317. |
| APA | Lu, DY.,Chen, XL.,Cao, JY.,Li, Z.,Xue, HW.,...&Xu, B.(2000).Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,28(6),313-317. |
| MLA | Lu, DY,et al."Effects of cancer chemotherapy on the blood fibrinogen concentrations of cancer patients".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 28.6(2000):313-317. |
入库方式： OAI收割
来源：上海药物研究所
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