Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons
文献类型：期刊论文
| 作者 | Ma, TC; Zhu, XZ |
| 刊名 | ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
 |
| 出版日期 | 2000-06 |
| 卷号 | 50期号:6页码:512-514 |
| 关键词 | CAS 2149-70-4 CAS 13755-38-9 interleukin-6 neurotoxicity, cell culture, hippocampal nitric oxide |
| ISSN号 | 0004-4172 |
| 文献子类 | Article |
| 英文摘要 | The neurotoxicity of interleukin-6 (IL-6) and sodium nitroprusside (SNP, CAS 13755-38-9) was examined using primary cultures of rat hippocampal neurons. The cell viability was significantly reduced after the cultures were cn-incubated with IL-6 4, 40, 400 ng/ml or SNP 1, 10, 100 mu mol/l for 23 h. In addition, N omega-nitro-L-arginine (NNA, CAS 2149-70-4) at 0.1 mmol/l, when so-added with 1L-6 400 ng/ml in cultures, significantly increased IL-6 reduced viability from 78.3 +/- 6.7 % to 113.3 +/- 10.0 %. These results indicate that IL-6 exerts neurotoxicity on cultured hippocampal neurons probably via overformation of nitric oxide in cultures. |
| WOS关键词 | ALZHEIMERS-DISEASE ; NERVOUS-SYSTEM ; EXPRESSION ; CORTEX |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000087965100002 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274615]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, TC,Zhu, XZ. Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons[J]. ARZNEIMITTELFORSCHUNG-DRUG RESEARCH,2000,50(6):512-514. |
| APA | Ma, TC,&Zhu, XZ.(2000).Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons.ARZNEIMITTELFORSCHUNG-DRUG RESEARCH,50(6),512-514. |
| MLA | Ma, TC,et al."Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons".ARZNEIMITTELFORSCHUNG-DRUG RESEARCH 50.6(2000):512-514. |
入库方式： OAI收割
来源：上海药物研究所
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