中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons

文献类型:期刊论文

作者Ma, TC; Zhu, XZ
刊名ARZNEIMITTELFORSCHUNG-DRUG RESEARCH
出版日期2000-06
卷号50期号:6页码:512-514
关键词CAS 2149-70-4 CAS 13755-38-9 interleukin-6 neurotoxicity, cell culture, hippocampal nitric oxide
ISSN号0004-4172
文献子类Article
英文摘要The neurotoxicity of interleukin-6 (IL-6) and sodium nitroprusside (SNP, CAS 13755-38-9) was examined using primary cultures of rat hippocampal neurons. The cell viability was significantly reduced after the cultures were cn-incubated with IL-6 4, 40, 400 ng/ml or SNP 1, 10, 100 mu mol/l for 23 h. In addition, N omega-nitro-L-arginine (NNA, CAS 2149-70-4) at 0.1 mmol/l, when so-added with 1L-6 400 ng/ml in cultures, significantly increased IL-6 reduced viability from 78.3 +/- 6.7 % to 113.3 +/- 10.0 %. These results indicate that IL-6 exerts neurotoxicity on cultured hippocampal neurons probably via overformation of nitric oxide in cultures.
WOS关键词ALZHEIMERS-DISEASE ; NERVOUS-SYSTEM ; EXPRESSION ; CORTEX
WOS研究方向Pharmacology & Pharmacy ; Chemistry
语种英语
WOS记录号WOS:000087965100002
出版者GEORG THIEME VERLAG KG
源URL[http://119.78.100.183/handle/2S10ELR8/274615]  
专题中国科学院上海药物研究所
通讯作者Zhu, XZ
作者单位1.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71130 USA
2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式
GB/T 7714
Ma, TC,Zhu, XZ. Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons[J]. ARZNEIMITTELFORSCHUNG-DRUG RESEARCH,2000,50(6):512-514.
APA Ma, TC,&Zhu, XZ.(2000).Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons.ARZNEIMITTELFORSCHUNG-DRUG RESEARCH,50(6),512-514.
MLA Ma, TC,et al."Neurotoxic effects of interleukin-6 and sodium nitroprusside on cultured rat hippocampal neurons".ARZNEIMITTELFORSCHUNG-DRUG RESEARCH 50.6(2000):512-514.

入库方式: OAI收割

来源:上海药物研究所

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