Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats
文献类型：期刊论文
| 作者 | Ma, TC; Zhu, XZ |
| 刊名 | ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
 |
| 出版日期 | 2000-03 |
| 卷号 | 50期号:3页码:E227-E231 |
| 关键词 | CAS 53-86-1 CAS 2149-70-4 indometacin inlerleukin-6, in vivo studies, passive avoidance pharmacology 6-keto-prostaglandin F-1 alpha nitric oxide, hippocampal N-G-nitro-L-arginine |
| ISSN号 | 0004-4172 |
| 文献子类 | Article |
| 英文摘要 | Bilateral infusion of interleukin-6 (IL-6) 80 ng into the hippocampus has been shown to impair retention of a step-through passive avoidance task via shortening the step-through latency in testing. This infusion with IL-6 also increased the levels of nitrite and 6-ketoprostaglandin F-1 alpha (6-keto-PGF(1 alpha)) in rat hippocampus. In addition, intraperitoneal injection of N-G-nitro-L-arginine (CAS 2149-70-4) 100 mg/kg for 5 days improved the retention impairment induced by IL-6 and meanwhile antagonized the increase in nitrite levels. Furthermore, intraperitoneal injection with indometacin (CAS 53-86-1) 10 mg/kg daily for 5 days reduced the IL-6-induced increase in 6-keto-PGF(1 alpha) levels. These results indicate that IL-6 impairs retention of passive avoidance probably via the overproduction of nitric oxide (NO) and suggest that IL-6 may possess an inducible effect on NO synthase and cyclo-oxygenase in the hippocampus. These findings support the hypothesis that central IL-6 participates in the pathogenesis of Alzheimer's disease, and the overproduction of nitric oxide in the brain may partially mediate the amnesic effect of IL-6. |
| WOS关键词 | ALZHEIMERS-DISEASE ; OXIDE ; BRAIN |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000086331200001 |
| 出版者 | ECV-EDITIO CANTOR VERLAG MEDIZIN NATURWISSENSCHAFTEN |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274638]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Ma, TC |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China 2.Louisiana State Univ, Med Ctr, Dept Pharmacol & Therapeut, Shreveport, LA 71105 USA |
| 推荐引用方式 GB/T 7714 | Ma, TC,Zhu, XZ. Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats[J]. ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,2000,50(3):E227-E231. |
| APA | Ma, TC,&Zhu, XZ.(2000).Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats.ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH,50(3),E227-E231. |
| MLA | Ma, TC,et al."Effects of intrahippocampal infusion of interleukin-6 on passive avoidance and nitrite and prostaglandin levels in the hippocampus in rats".ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH 50.3(2000):E227-E231. |
入库方式： OAI收割
来源：上海药物研究所
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