Synthesis and pharmacological study of huperzine A-E2020 combined compound
文献类型：期刊论文
| 作者 | Zeng, FX; Jiang, HL ; Zhai, YF; Liu, DX; Zhang, HY; Chen, KX; Ji, RY
|
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2000 |
| 卷号 | 58期号:5页码:580-587 |
| 关键词 | huperzine A E2020 combined compound biological activity molecular docking |
| ISSN号 | 0567-7351 |
| 文献子类 | Article |
| 英文摘要 | The synthesis of huperzine - E2020 combined compound (1) has been accomplished and the activities of 1 and the intermediates 10 and 11 to inhibit the activity of acetylcholinesterase have been measured. Conformational analyses and molecular docking studies of E2020 and the eight isomers of 10 were carried out. The results indicated that binding energies of all isomers of 10 with TcAChE is much lower than E2020 except for RRZ, which might be the reason that the activity of 10 is lower than that of E2020. interaction pattern of RRZ in TcAChE was also studied. Both docking studies and binding energy showed that the biological activity of RRZ might be higher than that of E2020. |
| WOS关键词 | ACETYLCHOLINESTERASE INHIBITOR ; ANTICHOLINESTERASE ACTIVITY |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:506583 |
| WOS记录号 | WOS:000087607200020 |
| 出版者 | ACTA CHIMICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274650]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zeng, FX |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, FX,Jiang, HL,Zhai, YF,et al. Synthesis and pharmacological study of huperzine A-E2020 combined compound[J]. ACTA CHIMICA SINICA,2000,58(5):580-587. |
| APA | Zeng, FX.,Jiang, HL.,Zhai, YF.,Liu, DX.,Zhang, HY.,...&Ji, RY.(2000).Synthesis and pharmacological study of huperzine A-E2020 combined compound.ACTA CHIMICA SINICA,58(5),580-587. |
| MLA | Zeng, FX,et al."Synthesis and pharmacological study of huperzine A-E2020 combined compound".ACTA CHIMICA SINICA 58.5(2000):580-587. |
入库方式： OAI收割
来源：上海药物研究所
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