Protective effects of bilobalide on amyloid beta-peptide 25-35-induced PC12 cell cytotoxicity
文献类型：期刊论文
| 作者 | Zhou, LJ; Song, W; Zhu, XZ; Chen, ZL; Yin, ML; Cheng, XF |
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2000-01 |
| 卷号 | 21期号:1页码:75-79 |
| 关键词 | Ginkgo biloba bilobalide PC12 cells amyloid beta-protein lactate dehydrogenase lipid peroxidation superoxide dismutase catalase glutathione peroxidase |
| ISSN号 | 0253-9756 |
| 文献子类 | Article |
| 英文摘要 | AIM: To study the effect of bilobalide, a terpene extracted from the leaves of Ginkgo biloba, on beta-amyloid peptide fragment 25 - 35 (A beta 25 - 35)-induced PC12 cell cytotoxicity. METHODS: 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assay were used to measure the viability of PC12 cells. Thiobarbituric acid-reactive substances were measured to determine lipid peroxidation of cells. Antioxidant enzymes in PC12 cells were detected. RESULTS: Treatment of PC12 cells with A beta 25 - 35 (100 mu mol.L-1) for 24 h caused a great decrease in cell viability (P < 0.01 compared with control). Bilobalide 25 - 100 mu mol.L-1 dose-dependently attenuated the cytotoxic effect of A beta 25 35. Bilobalide also inhibited A beta 25 - 35 (100 mu mol. L-1)-induced elevation of lipid peroxidation smd decline of antioxidant enzyme activities. CONCLUSION: Bilobalide protected PC12 cells from A beta 25 35-induced cytotoxicity. |
| WOS关键词 | GINKGO-BILOBA ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; EXTRACT EGB-761 ; CALCIUM HOMEOSTASIS ; NEUROTOXICITY ; TOXICITY ; DEMENTIA ; NEURONS |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000084710700012 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274655]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhu, XZ |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol 1, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Phytochem, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, LJ,Song, W,Zhu, XZ,et al. Protective effects of bilobalide on amyloid beta-peptide 25-35-induced PC12 cell cytotoxicity[J]. ACTA PHARMACOLOGICA SINICA,2000,21(1):75-79. |
| APA | Zhou, LJ,Song, W,Zhu, XZ,Chen, ZL,Yin, ML,&Cheng, XF.(2000).Protective effects of bilobalide on amyloid beta-peptide 25-35-induced PC12 cell cytotoxicity.ACTA PHARMACOLOGICA SINICA,21(1),75-79. |
| MLA | Zhou, LJ,et al."Protective effects of bilobalide on amyloid beta-peptide 25-35-induced PC12 cell cytotoxicity".ACTA PHARMACOLOGICA SINICA 21.1(2000):75-79. |
入库方式： OAI收割
来源：上海药物研究所
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