Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound
文献类型：期刊论文
| 作者 | Zeng, FX; Jiang, HL ; Zhai, YF; Zhang, HY; Chen, KX; Ji, RY
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 1999-12-06 |
| 卷号 | 9期号:23页码:3279-3284 |
| ISSN号 | 0960-894X |
| DOI | 10.1016/S0960-894X(99)00597-1 |
| 文献子类 | Article |
| 英文摘要 | The synthesis of huperzine-E2020 combined compound (3) has been accomplished and the activities of 3 and the intermediates 12 and 13 to inhibit the activity of acetylcholinesterase have been measured. Conformation analyses and molecular docking studies of E2020 and the eight isomers of 12 were carried out. The results indicated that binding energies of all isomers of 12 with AChE was much lowe; than E2020 except for isomer RRZ, which might be the reason that the activity of 12 was lower than that of E2020. Interaction pattern of RRZ in AChE was also studied. Both binding energy and interaction pattern shows that the biological activity of RRZ might be higher than that of E2020. (C) 1999 Elsevier Science Ltd. Ail rights reserved. |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000084153400005 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274669]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zeng, FX |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, FX,Jiang, HL,Zhai, YF,et al. Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,1999,9(23):3279-3284. |
| APA | Zeng, FX,Jiang, HL,Zhai, YF,Zhang, HY,Chen, KX,&Ji, RY.(1999).Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,9(23),3279-3284. |
| MLA | Zeng, FX,et al."Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 9.23(1999):3279-3284. |
入库方式： OAI收割
来源：上海药物研究所
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