Antagonistic effect of l-stepholidine on striatal ischemic injury in rat
文献类型：期刊论文
| 作者 | Tang, FM; Ding, YM; Chen, YT ; Sun, YF; Wang, R; Zhang, GY; Jin, GZ
|
| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 1999-12 |
| 卷号 | 20期号:12页码:1073-1078 |
| 关键词 | dopamine stepholidine corpus striatum cerebral ischemia Ca2+-calmodulin dependent protein kinase lactate dehydrogenase |
| ISSN号 | 1671-4083 |
| 文献子类 | Article |
| 英文摘要 | AIM: To elucidate the protection of l-stepholidine (SPD) on neuronal morphology and function against the striatal ischemic injury in rat. METHODS: The forebrain ishemia to Sprague Dawley rats was induced with four-vessel occlusion. Histological examination was performed on the dorsolateral striatum with cresyl-violet stain. In striatal slices of rat as an in vitro ischemic model, the activity of calcium/calmodulin-dependent protein kinase II (CCDPK) and lactate dehydrogenase (LDH) was examined by the method of P-32-incorporation and colorimetry, respectively. RESULTS: In the SPD-treated groups, most of the neurons in the striatum kept the normal morphological appearance after 30-min ischemia followed by 6-h or 12-h reperfusion. The number of neurons was much more in SPD groups than that in vehicle group. The sparse and abnormal neurons were observed in the vehicle group. SPD attenuated the ischemic effect on the CCDPK activity in striatal slices. In addition, SPD inhibited the leakage of LDH from neurons induced by ischemia in incubated striatal slices. CONCLUSION: SPD protected striatal neurons against ischemic injury and antagonized the inhibitory action on CCDPK activity induced by ischemia. SPD reduced the leakage of LDH from striatal neurons induced by ischemia. |
| WOS关键词 | CEREBRAL-ISCHEMIA ; PROTEIN-KINASE ; DOPAMINE ; RECEPTORS ; NEURONS ; DAMAGE ; BRAIN |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| CSCD记录号 | CSCD:846005 |
| WOS记录号 | WOS:000084067200003 |
| 出版者 | ACTA PHARMACOLOGICA SINICA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/274671]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Jin, GZ |
| 作者单位 | 1.Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Xuzhou 221002, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, FM,Ding, YM,Chen, YT,et al. Antagonistic effect of l-stepholidine on striatal ischemic injury in rat[J]. ACTA PHARMACOLOGICA SINICA,1999,20(12):1073-1078. |
| APA | Tang, FM.,Ding, YM.,Chen, YT.,Sun, YF.,Wang, R.,...&Jin, GZ.(1999).Antagonistic effect of l-stepholidine on striatal ischemic injury in rat.ACTA PHARMACOLOGICA SINICA,20(12),1073-1078. |
| MLA | Tang, FM,et al."Antagonistic effect of l-stepholidine on striatal ischemic injury in rat".ACTA PHARMACOLOGICA SINICA 20.12(1999):1073-1078. |
入库方式： OAI收割
来源：上海药物研究所
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